CJC-1295
Long-acting GHRH analogue with Drug Affinity Complex
Human RCTHuman ClinicalAnimal
5 studies
Open record →Scientific Topic
IGF-1
Fator de crescimento que atua por IGF1R e participa de múltiplos processos de crescimento e metabolismo.
At a glance
Research Summary
- What is it?
- Fator de crescimento que atua por IGF1R e participa de múltiplos processos de crescimento e metabolismo.
- Why does it matter?
- This topic provides a conceptual bridge between 2 biological processes and 5 compounds.
- Key mechanisms
- GH / IGF-1 Axis · IGF1R → PI3K → AKT
- Key targets
- GHRHR · IGF1R
- Related compounds
- CJC-1295 · Tesamorelin · IGF-1 · IGF-1 LR3 · IGF-1 DES
- Human evidence
- No human studies indexed for this node.
- Main uncertainties
- The current index is curated but not exhaustive.
Biological context
BI
Growth Plate
biological process
Chondrocyte proliferation, hypertrophy, differentiation and endochondral ossification.
15 pathway5 target12 compound7 study→
BIMuscle Adaptation
biological process
Cellular responses of skeletal muscle to loading, unloading and metabolic demand.
4 pathway1 target8 compound→
CEPituitary Somatotrophs
cell type
Anterior-pituitary cells that synthesize and release growth hormone.
6 pathway3 target12 compound6 study→
CEOsteoblasts
cell type
Bone-forming cells that synthesize osteoid and participate in mineralization.
5 pathway3 target6 compound1 study→
CEOsteoclasts
cell type
Multinucleated cells specialized for resorption of mineralized bone.
5 pathway3 target6 compound1 study→
CEOsteocytes
cell type
Mature bone cells embedded in matrix that participate in mechanosensing and remodeling signals.
5 pathway3 target5 compound1 study→
CEChondrocytes
cell type
Primary cell type responsible for cartilage matrix formation and growth-plate activity.
10 pathway3 target4 compound1 study→
CEMyocytes
cell type
Differentiated contractile muscle cells.
3 pathway1 target6 compound→
CESatellite Cells
cell type
Resident skeletal-muscle progenitor cells involved in repair and adaptation.
3 pathway1 target6 compound→
Related Compounds
Tesamorelin
Stabilized GHRH analogue
Human RCT
1 study
Open record →IGF-1
Insulin-like growth factor 1
Data not indexed yet
0 studies
Open record →IGF-1 LR3
Long R3 IGF-1 analogue
Data not indexed yet
0 studies
Open record →IGF-1 DES
N-terminal IGF-1 fragment
Data not indexed yet
0 studies
Open record →Related Pathways
PA
GH / IGF-1 Axis
pathway
Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
14 pathway6 target27 compound7 study→
PAIGF1R → PI3K → AKT
pathway
Cascata de receptor tirosina-quinase associada a crescimento, sobrevivência e metabolismo celular.
5 pathway2 target19 compound6 study→
Evidência publicada
Estudos
human-rctProlonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalPulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analogJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalActivation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjectsGrowth Hormone & IGF Research · 2009animalOnce-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouseAmerican Journal of Physiology-Endocrinology and Metabolism · 2006animalHuman growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analogEndocrinology · 2005human-rctEffect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trialJAMA · 2014
No dead ends
Continue Exploring
CO
CJC-1295
compound
Long-acting GHRH analogue with Drug Affinity Complex
16 pathway6 target22 compound6 study→
COTesamorelin
compound
Stabilized GHRH analogue
18 pathway8 target26 compound7 study→
COIGF-1
compound
Insulin-like growth factor 1
18 pathway6 target18 compound7 study→
COIGF-1 LR3
compound
Long R3 IGF-1 analogue
8 pathway3 target13 compound6 study→
COIGF-1 DES
compound
N-terminal IGF-1 fragment
8 pathway3 target13 compound6 study→
PAGH / IGF-1 Axis
pathway
Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
14 pathway6 target27 compound7 study→
PAIGF1R → PI3K → AKT
pathway
Cascata de receptor tirosina-quinase associada a crescimento, sobrevivência e metabolismo celular.
5 pathway2 target19 compound6 study→