CJC-1295
Long-acting GHRH analogue with Drug Affinity Complex
Human RCTHuman ClinicalAnimal
5 studies
Open record →Scientific Topic
Growth Hormone
Hormônio peptídico pituitário integrado ao eixo somatotrófico.
At a glance
Research Summary
- What is it?
- Hormônio peptídico pituitário integrado ao eixo somatotrófico.
- Why does it matter?
- This topic provides a conceptual bridge between 2 biological processes and 3 compounds.
- Key mechanisms
- GH / IGF-1 Axis · GHRH Signaling
- Key targets
- GHRHR
- Related compounds
- CJC-1295 · CJC-1295 without DAC · Sermorelin
- Human evidence
- No human studies indexed for this node.
- Main uncertainties
- The current index is curated but not exhaustive.
Biological context
BI
Growth Plate
biological process
Chondrocyte proliferation, hypertrophy, differentiation and endochondral ossification.
15 pathway5 target12 compound7 study→
BIPituitary GH Release
biological process
Synthesis and pulsatile release of growth hormone by pituitary somatotrophs.
8 pathway3 target10 compound6 study→
CEPituitary Somatotrophs
cell type
Anterior-pituitary cells that synthesize and release growth hormone.
6 pathway3 target12 compound6 study→
Related Compounds
CJC-1295 without DAC
Catalogue term often associated with Modified GRF (1–29)
Data not indexed yet
0 studies
Open record →Sermorelin
GHRH(1–29) analogue
Data not indexed yet
0 studies
Open record →Related Pathways
Evidência publicada
Estudos
human-rctProlonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalPulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analogJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalActivation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjectsGrowth Hormone & IGF Research · 2009animalOnce-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouseAmerican Journal of Physiology-Endocrinology and Metabolism · 2006animalHuman growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analogEndocrinology · 2005
No dead ends
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CO
CJC-1295
compound
Long-acting GHRH analogue with Drug Affinity Complex
16 pathway6 target22 compound6 study→
COCJC-1295 without DAC
compound
Catalogue term often associated with Modified GRF (1–29)
10 pathway5 target16 compound6 study→
COSermorelin
compound
GHRH(1–29) analogue
16 pathway5 target19 compound6 study→
PAGH / IGF-1 Axis
pathway
Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
14 pathway6 target27 compound7 study→
PAGHRH Signaling
pathway
Ativação de GHRHR em somatotrofos com sinalização Gs, adenilil ciclase, cAMP e PKA.
6 pathway3 target21 compound6 study→