CJC-1295
Long-acting GHRH analogue with Drug Affinity Complex
Human RCTHuman ClinicalAnimal
5 studies
Open record →Tissue
Liver
Metabolic and endocrine organ involved in nutrient handling and systemic IGF-1 production.
At a glance
Research Summary
- What is it?
- Metabolic and endocrine organ involved in nutrient handling and systemic IGF-1 production.
- Why does it matter?
- This tissue provides anatomical context for 0 cell types and 8 connected pathways.
- Key mechanisms
- DAC-mediated Albumin Association · GH / IGF-1 Axis · GHRH Signaling · cAMP Signaling · IGF1R → PI3K → AKT · GLP-1 Signaling · AMPK · CNP / NPR-B Signaling
- Key targets
- GHRHR · IGF1R
- Related compounds
- CJC-1295 · Tesamorelin · IGF-1
- Human evidence
- No human studies indexed for this node.
- Main uncertainties
- The current index is curated but not exhaustive.
Relevant pathways
PA
DAC-mediated Albumin Association
pathway
Estratégia de extensão de exposição em que o grupo Drug Affinity Complex do CJC-1295 se associa à albumina circulante; albumina atua como carreador, não como receptor farmacológico.
5 pathway2 target17 compound5 study→
PAGH / IGF-1 Axis
pathway
Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
14 pathway6 target27 compound7 study→
PAGHRH Signaling
pathway
Ativação de GHRHR em somatotrofos com sinalização Gs, adenilil ciclase, cAMP e PKA.
6 pathway3 target21 compound6 study→
PAcAMP Signaling
pathway
Rede de segundo mensageiro gerada por adenilil ciclase e interpretada por efetores como PKA e EPAC.
6 pathway5 target20 compound7 study→
PAIGF1R → PI3K → AKT
pathway
Cascata de receptor tirosina-quinase associada a crescimento, sobrevivência e metabolismo celular.
5 pathway2 target19 compound6 study→
PAGLP-1 Signaling
pathway
Sinalização de GLP-1R relacionada a secreção de insulina, esvaziamento gástrico e circuitos de saciedade.
6 pathway4 target19 compound7 study→
PAAMPK
pathway
Sensor celular de energia que coordena respostas ao estado energético.
5 pathway4 target11 compound2 study→
PACNP / NPR-B Signaling
pathway
Sinalização do receptor guanilato ciclase NPR-B por CNP, relevante à biologia da cartilagem de crescimento.
9 pathway4 target10 compound1 study→
Related Compounds
Tesamorelin
Stabilized GHRH analogue
Human RCT
1 study
Open record →IGF-1
Insulin-like growth factor 1
Data not indexed yet
0 studies
Open record →Evidência publicada
Estudos
human-rctProlonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalPulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analogJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalActivation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjectsGrowth Hormone & IGF Research · 2009animalOnce-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouseAmerican Journal of Physiology-Endocrinology and Metabolism · 2006animalHuman growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analogEndocrinology · 2005human-rctEffect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trialJAMA · 2014
No dead ends