Teriparatide
PTH(1–34) analogue
Data not indexed yet
0 studies
Open record →Biological Target
PTH1R
Parathyroid hormone 1 receptor
PTH1R is a class b g protein-coupled receptor connected to Gs / cAMP, Gq / PLC, Context-dependent bone signaling.
At a glance
Research Summary
- What is it?
- Receptor: Class B G protein-coupled receptor
- Why does it matter?
- This target connects ligands and 2 indexed compounds to downstream signaling.
- Key mechanisms
- IHH / PTHrP Feedback · PTH / PTH1R Signaling
- Key targets
- PTH1R
- Related compounds
- Teriparatide · Abaloparatide
- Human evidence
- 0 related study records are currently indexed.
- Main uncertainties
- Tissue expression and downstream effects vary by cell state, dose and experimental context.
Target profile
Canonical details
- Canonical name
- PTH1R
- Aliases
- Parathyroid hormone 1 receptor
- Target type
- Receptor
- Receptor class
- Class B G protein-coupled receptor
- Endogenous ligands
- PTH, PTHrP
- Downstream signaling
- Gs / cAMP → Gq / PLC → Context-dependent bone signaling
Curated relationships
direct
IHH / PTHrP Feedback acts on PTH1R.
mechanisticdirect
PTH / PTH1R Signaling acts on PTH1R.
humandirect
Teriparatide acts on PTH1R.
scope not indexeddirect
Abaloparatide acts on PTH1R.
scope not indexedPathways, tissues and cells
PA
IHH / PTHrP Feedback
pathway
Circuito regulatório entre Indian hedgehog e PTHrP associado à progressão de estados de diferenciação dos condrócitos.
9 pathway3 target14 compound→
PAPTH / PTH1R Signaling
pathway
Sinalização de PTH1R por PTH e PTHrP através de múltiplos efetores, incluindo cAMP/PKA.
2 pathway1 target14 compound→
TIBone
tissue
Mineralized connective tissue maintained by coordinated formation and resorption.
7 pathway3 target24 compound1 study→
Related Compounds
Abaloparatide
PTHrP analogue
Data not indexed yet
0 studies
Open record →Evidência publicada
Estudos
Nenhum estudo desta categoria de evidência foi indexado para este nó.
No dead ends
Continue Exploring
PA
IHH / PTHrP Feedback
pathway
Circuito regulatório entre Indian hedgehog e PTHrP associado à progressão de estados de diferenciação dos condrócitos.
9 pathway3 target14 compound→
PAPTH / PTH1R Signaling
pathway
Sinalização de PTH1R por PTH e PTHrP através de múltiplos efetores, incluindo cAMP/PKA.
2 pathway1 target14 compound→
COTeriparatide
compound
PTH(1–34) analogue
15 pathway5 target13 compound7 study→
COAbaloparatide
compound
PTHrP analogue
15 pathway5 target13 compound7 study→