PT-141 / Bremelanotide
Melanocortin receptor agonist
Data not indexed yet
0 studies
Open record →Biological Target
MC1R
Melanocortin 1 receptor
MC1R is a class a g protein-coupled receptor connected to Gs, cAMP, Melanogenesis.
At a glance
Research Summary
- What is it?
- Receptor: Class A G protein-coupled receptor
- Why does it matter?
- This target connects ligands and 3 indexed compounds to downstream signaling.
- Key mechanisms
- Melanocortin Signaling
- Key targets
- MC1R
- Related compounds
- PT-141 / Bremelanotide · Afamelanotide · Melanotan II
- Human evidence
- 0 related study records are currently indexed.
- Main uncertainties
- Tissue expression and downstream effects vary by cell state, dose and experimental context.
Target profile
Canonical details
- Canonical name
- MC1R
- Aliases
- Melanocortin 1 receptor
- Target type
- Receptor
- Receptor class
- Class A G protein-coupled receptor
- Endogenous ligands
- α-MSH
- Downstream signaling
- Gs → cAMP → Melanogenesis
Curated relationships
direct
Melanocortin Signaling acts on MC1R.
mechanisticdirect
MC1R expressed in Melanocytes.
scope not indexeddirect
PT-141 / Bremelanotide acts on MC1R.
scope not indexeddirect
Afamelanotide acts on MC1R.
scope not indexeddirect
Melanotan II acts on MC1R.
scope not indexedPathways, tissues and cells
PA
Melanocortin Signaling
pathway
Família de receptores ativados por peptídeos derivados de POMC, com funções dependentes do subtipo receptor e tecido.
3 target26 compound→
TISkin
tissue
Barrier organ containing epidermal, dermal, vascular and immune compartments.
4 pathway1 target12 compound15 study→
TIBrain
tissue
Central nervous system tissue integrating neural, endocrine and metabolic signals.
5 pathway5 target24 compound1 study→
TIPituitary
tissue
Endocrine gland containing hormone-secreting cell populations including somatotrophs.
9 pathway4 target25 compound6 study→
CEMelanocytes
cell type
Pigment-producing cells that synthesize melanin and transfer melanosomes to keratinocytes.
4 pathway1 target8 compound15 study→
Related Compounds
Afamelanotide
α-MSH analogue
Data not indexed yet
0 studies
Open record →Melanotan II
Cyclic melanocortin analogue
Data not indexed yet
0 studies
Open record →Evidência publicada
Estudos
Nenhum estudo desta categoria de evidência foi indexado para este nó.
No dead ends
Continue Exploring
PA
Melanocortin Signaling
pathway
Família de receptores ativados por peptídeos derivados de POMC, com funções dependentes do subtipo receptor e tecido.
3 target26 compound→
CEMelanocytes
cell type
Pigment-producing cells that synthesize melanin and transfer melanosomes to keratinocytes.
4 pathway1 target8 compound15 study→
COPT-141 / Bremelanotide
compound
Melanocortin receptor agonist
9 pathway7 target20 compound7 study→
COAfamelanotide
compound
α-MSH analogue
4 pathway1 target7 compound15 study→
COMelanotan II
compound
Cyclic melanocortin analogue
4 pathway1 target7 compound15 study→