IGF-1
Insulin-like growth factor 1
Data not indexed yet
0 studies
Open record →Biological Target
IGF1R
Insulin-like growth factor 1 receptor
IGF1R is a receptor tyrosine kinase connected to IRS, PI3K / AKT, RAS / MAPK.
At a glance
Research Summary
- What is it?
- Receptor: Receptor tyrosine kinase
- Why does it matter?
- This target connects ligands and 3 indexed compounds to downstream signaling.
- Key mechanisms
- IGF1R → PI3K → AKT
- Key targets
- IGF1R
- Related compounds
- IGF-1 · IGF-1 LR3 · IGF-1 DES
- Human evidence
- 0 related study records are currently indexed.
- Main uncertainties
- Tissue expression and downstream effects vary by cell state, dose and experimental context.
Target profile
Canonical details
- Canonical name
- IGF1R
- Aliases
- Insulin-like growth factor 1 receptor
- Target type
- Receptor
- Receptor class
- Receptor tyrosine kinase
- Endogenous ligands
- IGF-1, IGF-2
- Downstream signaling
- IRS → PI3K / AKT → RAS / MAPK
Curated relationships
direct
IGF1R → PI3K → AKT acts on IGF1R.
mechanisticdirect
IGF-1 acts on IGF1R.
scope not indexeddirect
IGF-1 LR3 acts on IGF1R.
scope not indexeddirect
IGF-1 DES acts on IGF1R.
scope not indexedPathways, tissues and cells
PA
IGF1R → PI3K → AKT
pathway
Cascata de receptor tirosina-quinase associada a crescimento, sobrevivência e metabolismo celular.
5 pathway2 target19 compound6 study→
TIBone
tissue
Mineralized connective tissue maintained by coordinated formation and resorption.
7 pathway3 target24 compound1 study→
TICartilage
tissue
Avascular connective tissue whose specialized cells maintain a proteoglycan-rich matrix.
6 pathway3 target20 compound1 study→
TISkeletal Muscle
tissue
Contractile tissue with mature myofibers and resident progenitor cells.
4 pathway1 target19 compound→
TILiver
tissue
Metabolic and endocrine organ involved in nutrient handling and systemic IGF-1 production.
8 pathway3 target27 compound6 study→
Related Compounds
IGF-1 LR3
Long R3 IGF-1 analogue
Data not indexed yet
0 studies
Open record →IGF-1 DES
N-terminal IGF-1 fragment
Data not indexed yet
0 studies
Open record →Evidência publicada
Estudos
Nenhum estudo desta categoria de evidência foi indexado para este nó.
No dead ends
Continue Exploring
PA
IGF1R → PI3K → AKT
pathway
Cascata de receptor tirosina-quinase associada a crescimento, sobrevivência e metabolismo celular.
5 pathway2 target19 compound6 study→
COIGF-1
compound
Insulin-like growth factor 1
18 pathway6 target18 compound7 study→
COIGF-1 LR3
compound
Long R3 IGF-1 analogue
8 pathway3 target13 compound6 study→
COIGF-1 DES
compound
N-terminal IGF-1 fragment
8 pathway3 target13 compound6 study→