CJC-1295
Long-acting GHRH analogue with Drug Affinity Complex
Human RCTHuman ClinicalAnimal
5 studies
Open record →Biological Target
GHRHR
Growth hormone-releasing hormone receptor
GHRHR is a class b g protein-coupled receptor connected to Gs, Adenylyl cyclase, cAMP, PKA, GH release.
At a glance
Research Summary
- What is it?
- Receptor: Class B G protein-coupled receptor
- Why does it matter?
- This target connects ligands and 4 indexed compounds to downstream signaling.
- Key mechanisms
- GHRH Signaling
- Key targets
- GHRHR
- Related compounds
- CJC-1295 · CJC-1295 without DAC · Sermorelin · Tesamorelin
- Human evidence
- 6 related study records are currently indexed.
- Main uncertainties
- Tissue expression and downstream effects vary by cell state, dose and experimental context.
Target profile
Canonical details
- Canonical name
- GHRHR
- Aliases
- Growth hormone-releasing hormone receptor
- Target type
- Receptor
- Receptor class
- Class B G protein-coupled receptor
- Endogenous ligands
- GHRH
- Downstream signaling
- Gs → Adenylyl cyclase → cAMP → PKA → GH release
Curated relationships
direct
GHRH Signaling acts on GHRHR.
mixeddirect
GHRHR expressed in Pituitary Somatotrophs.
scope not indexeddirect
CJC-1295 retained agonist activity at GHRHR in preclinical characterization.
mixeddirect
CJC-1295 acts on GHRHR.
scope not indexeddirect
CJC-1295 without DAC acts on GHRHR.
scope not indexeddirect
Sermorelin acts on GHRHR.
scope not indexeddirect
Tesamorelin acts on GHRHR.
scope not indexedPathways, tissues and cells
PA
GHRH Signaling
pathway
Ativação de GHRHR em somatotrofos com sinalização Gs, adenilil ciclase, cAMP e PKA.
6 pathway3 target21 compound6 study→
TIPituitary
tissue
Endocrine gland containing hormone-secreting cell populations including somatotrophs.
9 pathway4 target25 compound6 study→
TILiver
tissue
Metabolic and endocrine organ involved in nutrient handling and systemic IGF-1 production.
8 pathway3 target27 compound6 study→
TIAdipose Tissue
tissue
Energy-storing and endocrine tissue composed of adipocytes and stromal cells.
7 pathway5 target25 compound2 study→
CEPituitary Somatotrophs
cell type
Anterior-pituitary cells that synthesize and release growth hormone.
6 pathway3 target12 compound6 study→
Related Compounds
CJC-1295 without DAC
Catalogue term often associated with Modified GRF (1–29)
Data not indexed yet
0 studies
Open record →Sermorelin
GHRH(1–29) analogue
Data not indexed yet
0 studies
Open record →Tesamorelin
Stabilized GHRH analogue
Human RCT
1 study
Open record →Evidência publicada
Estudos
human-rctProlonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalPulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analogJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalActivation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjectsGrowth Hormone & IGF Research · 2009animalOnce-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouseAmerican Journal of Physiology-Endocrinology and Metabolism · 2006animalHuman growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analogEndocrinology · 2005human-rctEffect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trialJAMA · 2014
No dead ends
Continue Exploring
PA
GHRH Signaling
pathway
Ativação de GHRHR em somatotrofos com sinalização Gs, adenilil ciclase, cAMP e PKA.
6 pathway3 target21 compound6 study→
CEPituitary Somatotrophs
cell type
Anterior-pituitary cells that synthesize and release growth hormone.
6 pathway3 target12 compound6 study→
COCJC-1295
compound
Long-acting GHRH analogue with Drug Affinity Complex
16 pathway6 target22 compound6 study→
COCJC-1295 without DAC
compound
Catalogue term often associated with Modified GRF (1–29)
10 pathway5 target16 compound6 study→
COSermorelin
compound
GHRH(1–29) analogue
16 pathway5 target19 compound6 study→
COTesamorelin
compound
Stabilized GHRH analogue
18 pathway8 target26 compound7 study→