In VitroHuman cell culture
Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+
Y. Wegrowski, F. X. Maquart, J. P. Borel
Study design
Methods snapshot
- Population
- Normal human fibroblasts
- Sample size
- Not indexed
- Intervention
- GHK-Cu
- Route
- Not indexed
- Dose reported
- Concentration-response experiment; maximal response reported at 10⁻⁹ to 10⁻⁸ M
- Frequency
- Not indexed
- Duration
- Not indexed
- Control / placebo
- Not indexed
Outcomes
Primary
- Glycosaminoglycan synthesis
Results
GHK-Cu produced a biphasic concentration-dependent increase in selected extracellular and cell-associated glycosaminoglycans.
Interpretation
Supports a fibroblast matrix-response mechanism.
Adverse events
Not indexed in the current record.
Limitations
- In vitro concentration is not a human dose
Connected records
Original source
Sempre consulte o artigo original para métodos completos, análises e contexto editorial.
Open PubMed record ↗