In VitroIn vitro cell systems
Glycyl-l-histidyl-l-lysine prevents copper- and zinc-induced protein aggregation and central nervous system cell death in vitro
J. H. Min, H. Sarlus, R. A. Harris
Study design
Methods snapshot
- Population
- Central-nervous-system cell and protein-aggregation models
- Sample size
- Not indexed
- Intervention
- GHK-Cu
- Route
- Not indexed
- Dose reported
- Not indexed
- Frequency
- Not indexed
- Duration
- Not indexed
- Control / placebo
- Not indexed
Outcomes
Primary
- Metal-induced protein aggregation
- Cell death
Results
GHK reduced copper- and zinc-associated aggregation and cell death in vitro.
Interpretation
Mechanistic cytoprotection hypothesis requiring in vivo and clinical validation.
Adverse events
Not indexed in the current record.
Limitations
- The intervention centered on GHK metal binding in vitro
- No human neurodegenerative-disease outcome
Connected records
Original source
Sempre consulte o artigo original para métodos completos, análises e contexto editorial.
Open PubMed record ↗