AnimalRat / in vitro receptor systems
Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog
L. Jetté, R. Léger, K. Thibaudeau, C. Benquet, M. Robitaille, I. Pellerin, V. Paradis, P. van Wyk, K. Pham, D. P. Bridon
Study design
Methods snapshot
- Population
- Anterior-pituitary receptor assays and rat pharmacology
- Sample size
- Not indexed
- Intervention
- CJC-1295
- Route
- Not indexed
- Dose reported
- Not indexed
- Frequency
- Not indexed
- Duration
- Not indexed
- Control / placebo
- Not indexed
Outcomes
Primary
- GHRHR activation
- Albumin association
- Duration of pharmacological activity
Results
The study characterized albumin-binding hGRF analogues and identified CJC-1295 as a long-lasting GHRHR agonist.
Interpretation
Foundational evidence for DAC-mediated exposure extension and retained receptor agonism.
Adverse events
Not indexed in the current record.
Limitations
- Preclinical discovery study
- Does not establish clinical efficacy
Connected records
Original source
Sempre consulte o artigo original para métodos completos, análises e contexto editorial.
Open PubMed record ↗