IGF-1
Insulin-like growth factor 1
Data not indexed yet
0 studies
Open record →Research Area
Muscle & Performance Research
Biologia muscular, adaptação, massa magra e recuperação funcional.
At a glance
Research Summary
- What is it?
- Biologia muscular, adaptação, massa magra e recuperação funcional.
- Why does it matter?
- `This hub organizes ${processes.length} biological processes without treating a research category as a causal mechanism.`
- Key mechanisms
- IGF1R → PI3K → AKT · mTOR · GH / IGF-1 Axis · CNP / NPR-B Signaling
- Key targets
- Not indexed yet
- Related compounds
- IGF-1 · IGF-1 LR3 · IGF-1 DES
- Human evidence
- 0 directly or transitively connected human/curated study records are currently indexed.
- Main uncertainties
- Coverage is selective. A missing connection means it has not been curated here, not that no relationship exists.
Choose a level
What do you want to explore?
01
Muscle Adaptation
biological process
Cellular responses of skeletal muscle to loading, unloading and metabolic demand.
4 pathway1 target8 compound→
02Muscle Protein Turnover
biological process
Context-dependent balance between protein synthesis and degradation.
3 pathway1 target3 compound→
03Satellite Cell Activity
biological process
Activation and differentiation of skeletal-muscle progenitor cells.
3 pathway1 target6 compound→
04Functional Recovery
biological process
Restoration of tissue function after physiological stress or injury.
3 pathway1 target3 compound→
Key pathways
PA
IGF1R → PI3K → AKT
pathway
Cascata de receptor tirosina-quinase associada a crescimento, sobrevivência e metabolismo celular.
5 pathway2 target19 compound6 study→
PAmTOR
pathway
Rede central de integração de nutrientes, energia e sinais de crescimento.
3 compound→
PAGH / IGF-1 Axis
pathway
Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
14 pathway6 target27 compound7 study→
PACNP / NPR-B Signaling
pathway
Sinalização do receptor guanilato ciclase NPR-B por CNP, relevante à biologia da cartilagem de crescimento.
9 pathway4 target10 compound1 study→
Key cell types
CE
Satellite Cells
cell type
Resident skeletal-muscle progenitor cells involved in repair and adaptation.
3 pathway1 target6 compound→
CEMyocytes
cell type
Differentiated contractile muscle cells.
3 pathway1 target6 compound→
CEOsteoblasts
cell type
Bone-forming cells that synthesize osteoid and participate in mineralization.
5 pathway3 target6 compound1 study→
CEOsteoclasts
cell type
Multinucleated cells specialized for resorption of mineralized bone.
5 pathway3 target6 compound1 study→
CEOsteocytes
cell type
Mature bone cells embedded in matrix that participate in mechanosensing and remodeling signals.
5 pathway3 target5 compound1 study→
CEChondrocytes
cell type
Primary cell type responsible for cartilage matrix formation and growth-plate activity.
10 pathway3 target4 compound1 study→
Connected records
Related Compounds
IGF-1 LR3
Long R3 IGF-1 analogue
Data not indexed yet
0 studies
Open record →IGF-1 DES
N-terminal IGF-1 fragment
Data not indexed yet
0 studies
Open record →Evidência publicada
Estudos
Nenhum estudo desta categoria de evidência foi indexado para este nó.