PT-141 / Bremelanotide
Melanocortin receptor agonist
Data not indexed yet
0 studies
Open record →Biological Pathway / MC receptors
Melanocortin Signaling
Família de receptores ativados por peptídeos derivados de POMC, com funções dependentes do subtipo receptor e tecido.
At a glance
Research Summary
- What is it?
- Família de receptores ativados por peptídeos derivados de POMC, com funções dependentes do subtipo receptor e tecido.
- Why does it matter?
- Melanocortin Signaling connects 1 targets to 1 curated biological processes.
- Key mechanisms
- Melanocortin ligand · MC receptor subtype · Gs · cAMP · Tissue-specific response
- Key targets
- MC1R
- Related compounds
- PT-141 / Bremelanotide · Afamelanotide · Melanotan II
- Human evidence
- 0 related published study records are indexed.
- Main uncertainties
- Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.
Pathway profile
Canonical details
- Primary ligand
- Context dependent
- Target / receptor
- MC1R
- Second messenger
- cAMP
- Downstream pathway
- Gs → cAMP → Tissue-specific response
- Cell types
- Melanocytes
- Tissues
- Brain, Pituitary, Skin
- Physiological processes
- Pigmentation
- Known uncertainties
- Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.
Complementary visualization
Mechanism
Melanocortin ligand
↓
MC receptor subtype
↓
Gs
↓
cAMP
↓
Tissue-specific response
Arrows show a curated signaling sequence. They do not imply that every transition is a direct physical interaction.
Relationship evidence
directscope not indexed
Pigmentation associated with Melanocortin Signaling.
directmechanistic
Melanocortin Signaling acts on MC1R.
associatedscope not indexed
Melanocortin Signaling associated with PT-141 / Bremelanotide.
associatedscope not indexed
Melanocortin Signaling associated with Afamelanotide.
associatedscope not indexed
Melanocortin Signaling associated with Melanotan II.
associatedscope not indexed
Melanogenesis associated with Melanocortin Signaling.
Related Compounds
Afamelanotide
α-MSH analogue
Data not indexed yet
0 studies
Open record →Melanotan II
Cyclic melanocortin analogue
Data not indexed yet
0 studies
Open record →Related topics
Evidência publicada
Estudos
Nenhum estudo desta categoria de evidência foi indexado para este nó.
No dead ends
Continue Exploring
BI
Pigmentation
biological process
Melanin synthesis and distribution through melanocortin-dependent and local signaling.
4 pathway1 target4 compound15 study→
TAMC1R
target
MC1R is a class a g protein-coupled receptor connected to Gs, cAMP, Melanogenesis.
1 pathway2 target26 compound→
COPT-141 / Bremelanotide
compound
Melanocortin receptor agonist
9 pathway7 target20 compound7 study→
COAfamelanotide
compound
α-MSH analogue
4 pathway1 target7 compound15 study→
COMelanotan II
compound
Cyclic melanocortin analogue
4 pathway1 target7 compound15 study→
TOMelanogenesis
topic
Produção e distribuição de melanina por melanócitos.
1 pathway1 target8 compound→