Biological Pathway
MAPK
Família de cascatas quinase que transmite sinais de superfície ao programa celular.
At a glance
Research Summary
- What is it?
- Família de cascatas quinase que transmite sinais de superfície ao programa celular.
- Why does it matter?
- MAPK connects 1 targets to 1 curated biological processes.
- Key mechanisms
- Receptor · RAS · RAF · MEK · ERK
- Key targets
- NPR2 / NPR-B
- Related compounds
- Not indexed yet
- Human evidence
- 0 related published study records are indexed.
- Main uncertainties
- Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.
Pathway profile
Canonical details
- Primary ligand
- Context dependent
- Target / receptor
- NPR2 / NPR-B
- Second messenger
- Not indexed
- Downstream pathway
- RAF → MEK → ERK
- Cell types
- Chondrocytes
- Tissues
- Growth Plate, Cartilage, Bone
- Physiological processes
- Growth Plate
- Known uncertainties
- Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.
Complementary visualization
Mechanism
Arrows show a curated signaling sequence. They do not imply that every transition is a direct physical interaction.
Relationship evidence
Growth Plate associated with MAPK.
CNP/NPR2/cGMP signaling can oppose FGFR3-linked RAF/MEK/ERK signaling in growth-plate models.
FGFR3 / MAPK Signaling part of MAPK.
Related Compounds
Evidência publicada
Estudos
Nenhum estudo desta categoria de evidência foi indexado para este nó.
No dead ends
Continue Exploring
Growth Plate
biological process
Chondrocyte proliferation, hypertrophy, differentiation and endochondral ossification.
NPR2 / NPR-B
target
NPR2 / NPR-B is a membrane guanylyl cyclase receptor connected to cGMP, PKG, RAF / MEK / ERK modulation.
FGFR3 / MAPK Signaling
pathway
Sinalização de FGFR3 através de cascatas RAS/RAF/MEK/ERK, com efeitos dependentes do contexto na placa de crescimento.