IGF-1
Insulin-like growth factor 1
Data not indexed yet
0 studies
Open record →Biological Pathway / IGF1R
IGF1R → PI3K → AKT
Cascata de receptor tirosina-quinase associada a crescimento, sobrevivência e metabolismo celular.
At a glance
Research Summary
- What is it?
- Cascata de receptor tirosina-quinase associada a crescimento, sobrevivência e metabolismo celular.
- Why does it matter?
- IGF1R → PI3K → AKT connects 1 targets to 1 curated biological processes.
- Key mechanisms
- IGF1R · IRS · PI3K · AKT · Context-dependent cellular response
- Key targets
- IGF1R
- Related compounds
- IGF-1 · IGF-1 LR3 · IGF-1 DES
- Human evidence
- 0 related published study records are indexed.
- Main uncertainties
- Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.
Pathway profile
Canonical details
- Primary ligand
- IGF-1
- Target / receptor
- IGF1R
- Second messenger
- Not indexed
- Downstream pathway
- PI3K → AKT → Context-dependent cellular response
- Cell types
- Not indexed yet
- Tissues
- Skeletal Muscle, Bone, Cartilage, Liver, Pituitary, Adipose Tissue
- Physiological processes
- Muscle Adaptation
- Known uncertainties
- Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.
Complementary visualization
Mechanism
IGF1R
↓
IRS
↓
PI3K
↓
AKT
↓
Context-dependent cellular response
Arrows show a curated signaling sequence. They do not imply that every transition is a direct physical interaction.
Relationship evidence
directmechanistic
IGF1R → PI3K → AKT acts on IGF1R.
associatedmechanistic
Muscle Adaptation associated with IGF1R → PI3K → AKT.
associatedscope not indexed
IGF1R → PI3K → AKT associated with IGF-1.
associatedscope not indexed
IGF1R → PI3K → AKT associated with IGF-1 LR3.
associatedscope not indexed
IGF1R → PI3K → AKT associated with IGF-1 DES.
associatedscope not indexed
IGF-1 associated with IGF1R → PI3K → AKT.
Related Compounds
IGF-1 LR3
Long R3 IGF-1 analogue
Data not indexed yet
0 studies
Open record →IGF-1 DES
N-terminal IGF-1 fragment
Data not indexed yet
0 studies
Open record →Related topics
Evidência publicada
Estudos
Nenhum estudo desta categoria de evidência foi indexado para este nó.
No dead ends
Continue Exploring
TA
IGF1R
target
IGF1R is a receptor tyrosine kinase connected to IRS, PI3K / AKT, RAS / MAPK.
3 pathway19 compound→
BIMuscle Adaptation
biological process
Cellular responses of skeletal muscle to loading, unloading and metabolic demand.
4 pathway1 target8 compound→
COIGF-1
compound
Insulin-like growth factor 1
18 pathway6 target18 compound7 study→
COIGF-1 LR3
compound
Long R3 IGF-1 analogue
8 pathway3 target13 compound6 study→
COIGF-1 DES
compound
N-terminal IGF-1 fragment
8 pathway3 target13 compound6 study→
TOIGF-1
topic
Fator de crescimento que atua por IGF1R e participa de múltiplos processos de crescimento e metabolismo.
14 pathway3 target27 compound6 study→