CJC-1295
Long-acting GHRH analogue with Drug Affinity Complex
Human RCTHuman ClinicalAnimal
5 studies
Open record →Biological Pathway
GH / IGF-1 Axis
Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
At a glance
Research Summary
- What is it?
- Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
- Why does it matter?
- GH / IGF-1 Axis connects 0 targets to 1 curated biological processes.
- Key mechanisms
- Hypothalamic signals · Pituitary somatotroph · Growth hormone · Hepatic and local IGF-1 · IGF1R signaling
- Key targets
- Not indexed yet
- Related compounds
- CJC-1295 · Sermorelin · Tesamorelin · IGF-1
- Human evidence
- 6 related published study records are indexed.
- Main uncertainties
- Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.
Pathway profile
Canonical details
- Primary ligand
- IGF-1
- Target / receptor
- Not indexed yet
- Second messenger
- Not indexed
- Downstream pathway
- Growth hormone → Hepatic and local IGF-1 → IGF1R signaling
- Cell types
- Not indexed yet
- Tissues
- Growth Plate, Pituitary, Liver, Adipose Tissue, Bone, Cartilage, Skeletal Muscle
- Physiological processes
- Growth Plate
- Known uncertainties
- Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.
Complementary visualization
Mechanism
Hypothalamic signals
↓
Pituitary somatotroph ↓
Growth hormone ↓
Hepatic and local IGF-1
↓
IGF1R signaling
Arrows show a curated signaling sequence. They do not imply that every transition is a direct physical interaction.
Relationship evidence
associatedscope not indexed
Growth Plate associated with GH / IGF-1 Axis.
associatedscope not indexed
GH / IGF-1 Axis associated with CJC-1295.
associatedscope not indexed
GH / IGF-1 Axis associated with Sermorelin.
associatedscope not indexed
GH / IGF-1 Axis associated with Tesamorelin.
associatedscope not indexed
GH / IGF-1 Axis associated with IGF-1.
associatedscope not indexed
Growth Plate associated with GH / IGF-1 Axis.
associatedscope not indexed
Growth Hormone associated with GH / IGF-1 Axis.
associatedscope not indexed
IGF-1 associated with GH / IGF-1 Axis.
Related Compounds
Sermorelin
GHRH(1–29) analogue
Data not indexed yet
0 studies
Open record →Tesamorelin
Stabilized GHRH analogue
Human RCT
1 study
Open record →IGF-1
Insulin-like growth factor 1
Data not indexed yet
0 studies
Open record →Related topics
TO
Growth Plate
topic
Cartilagem organizada responsável pelo crescimento longitudinal ósseo durante o desenvolvimento.
13 pathway3 target20 compound7 study→
TOGrowth Hormone
topic
Hormônio peptídico pituitário integrado ao eixo somatotrófico.
13 pathway3 target20 compound6 study→
TOIGF-1
topic
Fator de crescimento que atua por IGF1R e participa de múltiplos processos de crescimento e metabolismo.
14 pathway3 target27 compound6 study→
Evidência publicada
Estudos
human-rctProlonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalPulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analogJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalActivation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjectsGrowth Hormone & IGF Research · 2009animalOnce-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouseAmerican Journal of Physiology-Endocrinology and Metabolism · 2006animalHuman growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analogEndocrinology · 2005human-rctEffect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trialJAMA · 2014
No dead ends
Continue Exploring
BI
Growth Plate
biological process
Chondrocyte proliferation, hypertrophy, differentiation and endochondral ossification.
15 pathway5 target12 compound7 study→
COCJC-1295
compound
Long-acting GHRH analogue with Drug Affinity Complex
16 pathway6 target22 compound6 study→
COSermorelin
compound
GHRH(1–29) analogue
16 pathway5 target19 compound6 study→
COTesamorelin
compound
Stabilized GHRH analogue
18 pathway8 target26 compound7 study→
COIGF-1
compound
Insulin-like growth factor 1
18 pathway6 target18 compound7 study→
TOGrowth Plate
topic
Cartilagem organizada responsável pelo crescimento longitudinal ósseo durante o desenvolvimento.
13 pathway3 target20 compound7 study→
TOGrowth Hormone
topic
Hormônio peptídico pituitário integrado ao eixo somatotrófico.
13 pathway3 target20 compound6 study→
TOIGF-1
topic
Fator de crescimento que atua por IGF1R e participa de múltiplos processos de crescimento e metabolismo.
14 pathway3 target27 compound6 study→