CJC-1295
Long-acting GHRH analogue with Drug Affinity Complex
Human RCTHuman ClinicalAnimal
5 studies
Open record →Biological Pathway
DAC-mediated Albumin Association
Estratégia de extensão de exposição em que o grupo Drug Affinity Complex do CJC-1295 se associa à albumina circulante; albumina atua como carreador, não como receptor farmacológico.
At a glance
Research Summary
- What is it?
- Estratégia de extensão de exposição em que o grupo Drug Affinity Complex do CJC-1295 se associa à albumina circulante; albumina atua como carreador, não como receptor farmacológico.
- Why does it matter?
- DAC-mediated Albumin Association connects 0 targets to 0 curated biological processes.
- Key mechanisms
- CJC-1295 with DAC · Reactive DAC group · Circulating albumin association · Extended systemic exposure · GHRHR agonism
- Key targets
- Not indexed yet
- Related compounds
- CJC-1295
- Human evidence
- 5 related published study records are indexed.
- Main uncertainties
- Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.
Pathway profile
Canonical details
- Primary ligand
- Context dependent
- Target / receptor
- Not indexed yet
- Second messenger
- Not indexed
- Downstream pathway
- Circulating albumin association → Extended systemic exposure → GHRHR agonism
- Cell types
- Not indexed yet
- Tissues
- Pituitary, Liver
- Physiological processes
- Not indexed yet
- Known uncertainties
- Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.
Complementary visualization
Mechanism
CJC-1295 with DAC
↓
Reactive DAC group
↓
Circulating albumin association
↓
Extended systemic exposure
↓
GHRHR agonism
Arrows show a curated signaling sequence. They do not imply that every transition is a direct physical interaction.
Relationship evidence
directmechanistic
The DAC group was designed to associate with albumin and extend systemic exposure.
associatedscope not indexed
DAC-mediated Albumin Association associated with CJC-1295.
Related Compounds
Evidência publicada
Estudos
human-rctProlonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalPulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analogJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalActivation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjectsGrowth Hormone & IGF Research · 2009animalOnce-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouseAmerican Journal of Physiology-Endocrinology and Metabolism · 2006animalHuman growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analogEndocrinology · 2005
No dead ends