CNP
C-type natriuretic peptide
Data not indexed yet
0 studies
Open record →Cell Type
Chondrocytes
Primary cell type responsible for cartilage matrix formation and growth-plate activity.
At a glance
Research Summary
- What is it?
- Primary cell type responsible for cartilage matrix formation and growth-plate activity.
- Why does it matter?
- This cell type is connected to 2 tissues and 1 biological processes in the current graph.
- Key mechanisms
- CNP / NPR-B Signaling · MAPK · FGFR3 / MAPK Signaling
- Key targets
- NPR2 / NPR-B · FGFR3
- Related compounds
- CNP · Vosoritide · Navepegritide / TransCon CNP · IGF-1
- Human evidence
- No human studies indexed for this node.
- Main uncertainties
- The current index is curated but not exhaustive.
Tissues and processes
TI
Growth Plate
tissue
Organized cartilage zones that support longitudinal bone growth before epiphyseal closure.
9 pathway3 target10 compound1 study→
TICartilage
tissue
Avascular connective tissue whose specialized cells maintain a proteoglycan-rich matrix.
6 pathway3 target20 compound1 study→
BIGrowth Plate
biological process
Chondrocyte proliferation, hypertrophy, differentiation and endochondral ossification.
15 pathway5 target12 compound7 study→
Pathways and targets
PA
CNP / NPR-B Signaling
pathway
Sinalização do receptor guanilato ciclase NPR-B por CNP, relevante à biologia da cartilagem de crescimento.
9 pathway4 target10 compound1 study→
PAMAPK
pathway
Família de cascatas quinase que transmite sinais de superfície ao programa celular.
8 pathway3 target9 compound1 study→
PAFGFR3 / MAPK Signaling
pathway
Sinalização de FGFR3 através de cascatas RAS/RAF/MEK/ERK, com efeitos dependentes do contexto na placa de crescimento.
8 pathway3 target9 compound→
TANPR2 / NPR-B
target
NPR2 / NPR-B is a membrane guanylyl cyclase receptor connected to cGMP, PKG, RAF / MEK / ERK modulation.
9 pathway1 target7 compound1 study→
TAFGFR3
target
FGFR3 is a receptor tyrosine kinase connected to RAS / RAF, MEK / ERK, Context-dependent growth-plate response.
8 pathway1 target4 compound→
Related Compounds
Vosoritide
CNP analogue
Human RCT
1 study
Open record →Navepegritide / TransCon CNP
Long-acting CNP prodrug
Data not indexed yet
0 studies
Open record →IGF-1
Insulin-like growth factor 1
Data not indexed yet
0 studies
Open record →Evidência publicada
Estudos
No dead ends
Continue Exploring
TI
Growth Plate
tissue
Organized cartilage zones that support longitudinal bone growth before epiphyseal closure.
9 pathway3 target10 compound1 study→
TANPR2 / NPR-B
target
NPR2 / NPR-B is a membrane guanylyl cyclase receptor connected to cGMP, PKG, RAF / MEK / ERK modulation.
9 pathway1 target7 compound1 study→
TAFGFR3
target
FGFR3 is a receptor tyrosine kinase connected to RAS / RAF, MEK / ERK, Context-dependent growth-plate response.
8 pathway1 target4 compound→
TICartilage
tissue
Avascular connective tissue whose specialized cells maintain a proteoglycan-rich matrix.
6 pathway3 target20 compound1 study→