Ex VivoHuman tissue ex vivo
Human skin retention and penetration of a copper tripeptide in vitro as function of skin layer towards anti-inflammatory therapy
J. J. Hostynek, F. Dreher, H. I. Maibach
Study design
Methods snapshot
- Population
- Isolated stratum corneum, epidermis and dermatomed human skin
- Sample size
- Not indexed
- Intervention
- GHK-Cu
- Route
- Topical ex vivo
- Dose reported
- 0.68% aqueous copper as tripeptide under infinite-dose conditions
- Frequency
- Not indexed
- Duration
- 48 hours
- Control / placebo
- Not indexed
Outcomes
Primary
- Copper permeation and retention by skin layer
Results
Copper from the tripeptide formulation permeated and was retained in ex vivo human skin under the test conditions.
Interpretation
Supports experimental skin disposition, not therapeutic benefit.
Adverse events
Not indexed in the current record.
Limitations
- Ex vivo infinite-dose experiment
- Does not establish clinical anti-inflammatory efficacy
Connected records
Original source
Sempre consulte o artigo original para métodos completos, análises e contexto editorial.
Open PubMed record ↗