CJC-1295
Long-acting GHRH analogue with Drug Affinity Complex
Human RCTHuman ClinicalAnimal
5 studies
Open record →Research Area
GH / IGF Axis
Regulação de GHRH, secreção de GH, IGF-1 e sinalização somatotrófica.
At a glance
Research Summary
- What is it?
- Regulação de GHRH, secreção de GH, IGF-1 e sinalização somatotrófica.
- Why does it matter?
- `This hub organizes ${processes.length} biological processes without treating a research category as a causal mechanism.`
- Key mechanisms
- DAC-mediated Albumin Association · GH / IGF-1 Axis · GHRH Signaling · cAMP Signaling · Ghrelin / GHSR
- Key targets
- Not indexed yet
- Related compounds
- CJC-1295 · CJC-1295 without DAC · Sermorelin · Tesamorelin · Ipamorelin
- Human evidence
- 6 directly or transitively connected human/curated study records are currently indexed.
- Main uncertainties
- Coverage is selective. A missing connection means it has not been curated here, not that no relationship exists.
Choose a level
What do you want to explore?
Key pathways
PA
DAC-mediated Albumin Association
pathway
Estratégia de extensão de exposição em que o grupo Drug Affinity Complex do CJC-1295 se associa à albumina circulante; albumina atua como carreador, não como receptor farmacológico.
5 pathway2 target17 compound5 study→
PAGH / IGF-1 Axis
pathway
Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
14 pathway6 target27 compound7 study→
PAGHRH Signaling
pathway
Ativação de GHRHR em somatotrofos com sinalização Gs, adenilil ciclase, cAMP e PKA.
6 pathway3 target21 compound6 study→
PAcAMP Signaling
pathway
Rede de segundo mensageiro gerada por adenilil ciclase e interpretada por efetores como PKA e EPAC.
6 pathway5 target20 compound7 study→
PAGhrelin / GHSR
pathway
Sinalização do receptor secretagogo de GH e seus efeitos neuroendócrinos.
1 target15 compound→
PAIGF1R → PI3K → AKT
pathway
Cascata de receptor tirosina-quinase associada a crescimento, sobrevivência e metabolismo celular.
5 pathway2 target19 compound6 study→
Key cell types
CE
Pituitary Somatotrophs
cell type
Anterior-pituitary cells that synthesize and release growth hormone.
6 pathway3 target12 compound6 study→
CEOsteoblasts
cell type
Bone-forming cells that synthesize osteoid and participate in mineralization.
5 pathway3 target6 compound1 study→
CEOsteoclasts
cell type
Multinucleated cells specialized for resorption of mineralized bone.
5 pathway3 target6 compound1 study→
CEOsteocytes
cell type
Mature bone cells embedded in matrix that participate in mechanosensing and remodeling signals.
5 pathway3 target5 compound1 study→
CEChondrocytes
cell type
Primary cell type responsible for cartilage matrix formation and growth-plate activity.
10 pathway3 target4 compound1 study→
CEMyocytes
cell type
Differentiated contractile muscle cells.
3 pathway1 target6 compound→
Connected records
Related Compounds
CJC-1295 without DAC
Catalogue term often associated with Modified GRF (1–29)
Data not indexed yet
0 studies
Open record →Sermorelin
GHRH(1–29) analogue
Data not indexed yet
0 studies
Open record →Tesamorelin
Stabilized GHRH analogue
Human RCT
1 study
Open record →Ipamorelin
Selective ghrelin receptor agonist
Data not indexed yet
0 studies
Open record →GHRP-2
Growth hormone secretagogue
Data not indexed yet
0 studies
Open record →GHRP-6
Growth hormone secretagogue
Data not indexed yet
0 studies
Open record →Hexarelin
Growth hormone secretagogue
Data not indexed yet
0 studies
Open record →IGF-1
Insulin-like growth factor 1
Data not indexed yet
0 studies
Open record →IGF-1 LR3
Long R3 IGF-1 analogue
Data not indexed yet
0 studies
Open record →IGF-1 DES
N-terminal IGF-1 fragment
Data not indexed yet
0 studies
Open record →Published evidence
Studies
human-rctProlonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalPulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analogJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalActivation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjectsGrowth Hormone & IGF Research · 2009animalOnce-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouseAmerican Journal of Physiology-Endocrinology and Metabolism · 2006animalHuman growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analogEndocrinology · 2005human-rctEffect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trialJAMA · 2014