Tesamorelin
Stabilized GHRH analogue
Tesamorelin é um análogo de GHRH estudado clinicamente no contexto de acúmulo de gordura abdominal associado ao HIV.[1]
01 / Overview
Quick facts
Somente campos atualmente documentados aparecem neste registro.
- class
- GHRH analogue
- receptor
- GHRHR
- primary Axis
- GH / IGF-1
- research Status
- Approved drug
What is it studied for?
The indexed randomized trial measured visceral and liver fat over six months.
02 / Mechanism
Mechanism of action
Fluxo estruturado para navegação. Uma seta indica sequência conceitual, não necessariamente interação direta.
03 / Evidence synthesis
What does the evidence actually show?
As categorias evitam misturar evidência humana, dados pré-clínicos e plausibilidade mecanística. A cobertura desta versão não é uma revisão sistemática.
Data not indexed yet.
Data not indexed yet.
Data not indexed yet.
Data not indexed yet.
Data not indexed yet.
Claims review not indexed yet.
04 / Published protocols
Dosing reported in published human studies
The values reproduce protocols described in published research. They are not recommendations, prescriptions or clinical guidance.
| Study | Population | N | Route | Dose reported | Frequency | Duration | Design | Primary outcome | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Takara L. Stanley et al. | Antiretroviral-treated adults with HIV and abdominal fat accumulation | 50 | Subcutaneous | 2 mg | Daily | 6 months | human-rct · not-extracted | Visceral adipose tissue; Liver fat | Open |
06 / Safety
Safety & Adverse Events
Reported findings
Data not indexed yet. Lack of indexed harm data is not evidence of safety.
Pharmacological concerns
Data not indexed yet. Lack of indexed harm data is not evidence of safety.
Unknowns
Data not indexed yet. Lack of indexed harm data is not evidence of safety.
07 / Source literature
Studies
Multiple entry points
Related Paths
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IGF-1
topic
Fator de crescimento que atua por IGF1R e participa de múltiplos processos de crescimento e metabolismo.
Insulin Resistance
topic
Redução da resposta biológica à insulina em tecidos metabólicos.
GHRH Signaling
pathway
Ativação de GHRHR em somatotrofos com sinalização Gs, adenilil ciclase, cAMP e PKA.
GH / IGF-1 Axis
pathway
Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
Pituitary
tissue
Endocrine gland containing hormone-secreting cell populations including somatotrophs.
Adipose Tissue
tissue
Energy-storing and endocrine tissue composed of adipocytes and stromal cells.
Liver
tissue
Metabolic and endocrine organ involved in nutrient handling and systemic IGF-1 production.
GHRHR
target
GHRHR is a class b g protein-coupled receptor connected to Gs, Adenylyl cyclase, cAMP, PKA, GH release.
09 / References
References
- [1]
Takara L. Stanley, Meghan N. Feldpausch, Jinhee Oh, Karen L. Branch, Hang Lee, Martin Torriani, Steven K. Grinspoon. Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial. JAMA. 2014.