GHK-Cu
Copper(II) complex of glycyl-L-histidyl-L-lysine
In VitroAnimalHuman RCTEx Vivo
15 studies
Open record →Scientific Topic
Collagen
Família de proteínas estruturais da matriz extracelular em pele, osso, cartilagem e outros tecidos.
At a glance
Research Summary
- What is it?
- Família de proteínas estruturais da matriz extracelular em pele, osso, cartilagem e outros tecidos.
- Why does it matter?
- This topic provides a conceptual bridge between 1 biological processes and 1 compounds.
- Key mechanisms
- Not indexed yet
- Key targets
- Not indexed yet
- Related compounds
- GHK-Cu
- Human evidence
- No human studies indexed for this node.
- Main uncertainties
- The current index is curated but not exhaustive.
Biological context
BI
Wound Healing
biological process
Inflammation, re-epithelialization, angiogenesis and tissue remodeling after injury.
4 pathway1 target7 compound15 study→
CEFibroblasts
cell type
Mesenchymal cells that synthesize and remodel extracellular matrix in connective tissues.
4 pathway1 target7 compound15 study→
CEKeratinocytes
cell type
Predominant epidermal cells that form and renew the skin barrier.
4 pathway1 target7 compound15 study→
CEMelanocytes
cell type
Pigment-producing cells that synthesize melanin and transfer melanosomes to keratinocytes.
4 pathway1 target8 compound15 study→
Related Compounds
Published evidence
Studies
in-vitroStructure of the Glycyl-L-histidyl-L-lysine--copper(II) complex in solutionBiochemistry · 1982in-vitroN.m.r. and e.p.r. investigation of the interaction of copper(II) and glycyl-L-histidyl-L-lysine, a growth-modulating tripeptide from plasmaBiochemical Journal · 1983in-vitroStimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+FEBS Letters · 1988in-vitroStimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+Life Sciences · 1992animalIn vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental woundsJournal of Clinical Investigation · 1993human-rctEnhanced healing of ulcers in patients with diabetes by topical treatment with glycyl-l-histidyl-l-lysine copperWound Repair and Regeneration · 1994in-vitroEffects of the tripeptide glycyl-L-histidyl-L-lysine copper complex on osteoblastic cell spreading, attachment and phenotypeCellular and Molecular Biology · 1995animalExpression and activation of matrix metalloproteinases in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+Journal of Investigative Dermatology · 1999in-vitroThe tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast culturesLife Sciences · 2000animalExpression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu(2+)Journal of Investigative Dermatology · 2000in-vitroESI-MS study of the mechanism of glycyl-l-histidyl-l-lysine-Cu(II) complex transport through model membrane of stratum corneumTalanta · 2007ex-vivoHuman skin retention and penetration of a copper tripeptide in vitro as function of skin layer towards anti-inflammatory therapyInflammation Research · 2010in-vitroTernary Cu2+ Complexes of Human Serum Albumin and Glycyl-l-histidyl-l-lysineInorganic Chemistry · 2021in-vitroGlycyl-l-histidyl-l-lysine prevents copper- and zinc-induced protein aggregation and central nervous system cell death in vitroMetallomics · 2024animalGlycyl-L-histidyl-L-lysine-Cu2+ (GHK-Cu) Attenuates CuSO4 or LPS induced-inflammation in Zebrafish larvae modelEuropean Journal of Pharmacology · 2026
No dead ends