IGF-1
Insulin-like growth factor 1
Data not indexed yet
0 studies
Open record →Tissue
Skeletal Muscle
Contractile tissue with mature myofibers and resident progenitor cells.
At a glance
Research Summary
- What is it?
- Contractile tissue with mature myofibers and resident progenitor cells.
- Why does it matter?
- This tissue provides anatomical context for 2 cell types and 4 connected pathways.
- Key mechanisms
- IGF1R → PI3K → AKT · GH / IGF-1 Axis · AMPK · CNP / NPR-B Signaling
- Key targets
- IGF1R
- Related compounds
- IGF-1 · IGF-1 LR3 · IGF-1 DES · MOTS-c · SS-31 / Elamipretide · Humanin
- Human evidence
- No human studies indexed for this node.
- Main uncertainties
- The current index is curated but not exhaustive.
Cell types
Biological processes
Relevant pathways
PA
IGF1R → PI3K → AKT
pathway
Cascata de receptor tirosina-quinase associada a crescimento, sobrevivência e metabolismo celular.
5 pathway2 target19 compound6 study→
PAGH / IGF-1 Axis
pathway
Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
14 pathway6 target27 compound7 study→
PAAMPK
pathway
Sensor celular de energia que coordena respostas ao estado energético.
5 pathway4 target11 compound2 study→
PACNP / NPR-B Signaling
pathway
Sinalização do receptor guanilato ciclase NPR-B por CNP, relevante à biologia da cartilagem de crescimento.
9 pathway4 target10 compound1 study→
Related Compounds
IGF-1 LR3
Long R3 IGF-1 analogue
Data not indexed yet
0 studies
Open record →IGF-1 DES
N-terminal IGF-1 fragment
Data not indexed yet
0 studies
Open record →MOTS-c
Mitochondrial-derived peptide
Data not indexed yet
0 studies
Open record →SS-31 / Elamipretide
Mitochondria-targeting tetrapeptide
Data not indexed yet
0 studies
Open record →Humanin
Mitochondrial-derived peptide
Data not indexed yet
0 studies
Open record →Published evidence
Studies
No studies in this evidence category are indexed for this node.
No dead ends
Continue Exploring
CE
Myocytes
cell type
Differentiated contractile muscle cells.
3 pathway1 target6 compound→
CESatellite Cells
cell type
Resident skeletal-muscle progenitor cells involved in repair and adaptation.
3 pathway1 target6 compound→
BIMuscle Adaptation
biological process
Cellular responses of skeletal muscle to loading, unloading and metabolic demand.
4 pathway1 target8 compound→
COIGF-1
compound
Insulin-like growth factor 1
18 pathway6 target18 compound7 study→
COIGF-1 LR3
compound
Long R3 IGF-1 analogue
8 pathway3 target13 compound6 study→
COIGF-1 DES
compound
N-terminal IGF-1 fragment
8 pathway3 target13 compound6 study→
COMOTS-c
compound
Mitochondrial-derived peptide
5 pathway1 target9 compound→
COSS-31 / Elamipretide
compound
Mitochondria-targeting tetrapeptide
5 pathway1 target9 compound→