CJC-1295
Long-acting GHRH analogue with Drug Affinity Complex
Human RCTHuman ClinicalAnimal
5 studies
Open record →Tissue
Pituitary
Endocrine gland containing hormone-secreting cell populations including somatotrophs.
At a glance
Research Summary
- What is it?
- Endocrine gland containing hormone-secreting cell populations including somatotrophs.
- Why does it matter?
- This tissue provides anatomical context for 1 cell types and 9 connected pathways.
- Key mechanisms
- Ghrelin / GHSR · DAC-mediated Albumin Association · GH / IGF-1 Axis · GHRH Signaling · cAMP Signaling · Melanocortin Signaling · IGF1R → PI3K → AKT · GLP-1 Signaling · AMPK
- Key targets
- GHSR · GHRHR · MC1R
- Related compounds
- CJC-1295 · CJC-1295 without DAC · Sermorelin · Tesamorelin · Ipamorelin · GHRP-2
- Human evidence
- No human studies indexed for this node.
- Main uncertainties
- The current index is curated but not exhaustive.
Cell types
Relevant pathways
PA
Ghrelin / GHSR
pathway
Sinalização do receptor secretagogo de GH e seus efeitos neuroendócrinos.
1 target15 compound→
PADAC-mediated Albumin Association
pathway
Estratégia de extensão de exposição em que o grupo Drug Affinity Complex do CJC-1295 se associa à albumina circulante; albumina atua como carreador, não como receptor farmacológico.
5 pathway2 target17 compound5 study→
PAGH / IGF-1 Axis
pathway
Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
14 pathway6 target27 compound7 study→
PAGHRH Signaling
pathway
Ativação de GHRHR em somatotrofos com sinalização Gs, adenilil ciclase, cAMP e PKA.
6 pathway3 target21 compound6 study→
PAcAMP Signaling
pathway
Rede de segundo mensageiro gerada por adenilil ciclase e interpretada por efetores como PKA e EPAC.
6 pathway5 target20 compound7 study→
PAMelanocortin Signaling
pathway
Família de receptores ativados por peptídeos derivados de POMC, com funções dependentes do subtipo receptor e tecido.
3 target26 compound→
PAIGF1R → PI3K → AKT
pathway
Cascata de receptor tirosina-quinase associada a crescimento, sobrevivência e metabolismo celular.
5 pathway2 target19 compound6 study→
PAGLP-1 Signaling
pathway
Sinalização de GLP-1R relacionada a secreção de insulina, esvaziamento gástrico e circuitos de saciedade.
6 pathway4 target19 compound7 study→
PAAMPK
pathway
Sensor celular de energia que coordena respostas ao estado energético.
5 pathway4 target11 compound2 study→
Related Compounds
CJC-1295 without DAC
Catalogue term often associated with Modified GRF (1–29)
Data not indexed yet
0 studies
Open record →Sermorelin
GHRH(1–29) analogue
Data not indexed yet
0 studies
Open record →Tesamorelin
Stabilized GHRH analogue
Human RCT
1 study
Open record →Ipamorelin
Selective ghrelin receptor agonist
Data not indexed yet
0 studies
Open record →GHRP-2
Growth hormone secretagogue
Data not indexed yet
0 studies
Open record →GHRP-6
Growth hormone secretagogue
Data not indexed yet
0 studies
Open record →Hexarelin
Growth hormone secretagogue
Data not indexed yet
0 studies
Open record →Kisspeptin-10
Kisspeptin fragment
Mecanismo estruturado ainda não indexado.
Data not indexed yet
0 studies
Open record →Kisspeptin-54
Endogenous kisspeptin isoform
Mecanismo estruturado ainda não indexado.
Data not indexed yet
0 studies
Open record →Gonadorelin
Synthetic GnRH
Mecanismo estruturado ainda não indexado.
Data not indexed yet
0 studies
Open record →PT-141 / Bremelanotide
Melanocortin receptor agonist
Data not indexed yet
0 studies
Open record →Published evidence
Studies
human-rctProlonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalPulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analogJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalActivation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjectsGrowth Hormone & IGF Research · 2009animalOnce-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouseAmerican Journal of Physiology-Endocrinology and Metabolism · 2006animalHuman growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analogEndocrinology · 2005human-rctEffect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trialJAMA · 2014
No dead ends
Continue Exploring
TA
GHSR
target
GHSR is a class a g protein-coupled receptor connected to Gq/11, PLC, Intracellular calcium.
6 pathway2 target15 compound6 study→
CEPituitary Somatotrophs
cell type
Anterior-pituitary cells that synthesize and release growth hormone.
6 pathway3 target12 compound6 study→
COCJC-1295
compound
Long-acting GHRH analogue with Drug Affinity Complex
16 pathway6 target22 compound6 study→
COCJC-1295 without DAC
compound
Catalogue term often associated with Modified GRF (1–29)
10 pathway5 target16 compound6 study→
COSermorelin
compound
GHRH(1–29) analogue
16 pathway5 target19 compound6 study→
COTesamorelin
compound
Stabilized GHRH analogue
18 pathway8 target26 compound7 study→
COIpamorelin
compound
Selective ghrelin receptor agonist
7 pathway4 target14 compound6 study→
COGHRP-2
compound
Growth hormone secretagogue
7 pathway4 target14 compound6 study→