CNP
C-type natriuretic peptide
Data not indexed yet
0 studies
Open record →Tissue
Growth Plate
Organized cartilage zones that support longitudinal bone growth before epiphyseal closure.
At a glance
Research Summary
- What is it?
- Organized cartilage zones that support longitudinal bone growth before epiphyseal closure.
- Why does it matter?
- This tissue provides anatomical context for 1 cell types and 9 connected pathways.
- Key mechanisms
- CNP / NPR-B Signaling · GH / IGF-1 Axis · MAPK · FGFR3 / MAPK Signaling · IHH / PTHrP Feedback · BMP Signaling · Wnt / β-catenin Signaling · Estrogen Signaling · cGMP Signaling
- Key targets
- NPR2 / NPR-B · FGFR3
- Related compounds
- CNP · Vosoritide · Navepegritide / TransCon CNP
- Human evidence
- No human studies indexed for this node.
- Main uncertainties
- The current index is curated but not exhaustive.
Cell types
Biological processes
Relevant pathways
PA
CNP / NPR-B Signaling
pathway
Sinalização do receptor guanilato ciclase NPR-B por CNP, relevante à biologia da cartilagem de crescimento.
9 pathway4 target10 compound1 study→
PAGH / IGF-1 Axis
pathway
Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
14 pathway6 target27 compound7 study→
PAMAPK
pathway
Família de cascatas quinase que transmite sinais de superfície ao programa celular.
8 pathway3 target9 compound1 study→
PAFGFR3 / MAPK Signaling
pathway
Sinalização de FGFR3 através de cascatas RAS/RAF/MEK/ERK, com efeitos dependentes do contexto na placa de crescimento.
8 pathway3 target9 compound→
PAIHH / PTHrP Feedback
pathway
Circuito regulatório entre Indian hedgehog e PTHrP associado à progressão de estados de diferenciação dos condrócitos.
9 pathway3 target14 compound→
PABMP Signaling
pathway
Sinalização de bone morphogenetic proteins por receptores serina/treonina-quinase e SMADs.
8 pathway3 target9 compound→
PAWnt / β-catenin Signaling
pathway
Via canônica de Wnt que estabiliza β-catenina e regula programas transcricionais dependentes do contexto.
8 pathway3 target9 compound→
PAEstrogen Signaling
pathway
Sinalização por receptores de estrogênio com efeitos genômicos e não genômicos dependentes de tecido e estágio de desenvolvimento.
8 pathway3 target9 compound→
PAcGMP Signaling
pathway
Rede de segundo mensageiro gerada por guanilato ciclases e interpretada por proteínas quinase dependentes de cGMP.
8 pathway1 target4 compound1 study→
Related Compounds
Vosoritide
CNP analogue
Human RCT
1 study
Open record →Navepegritide / TransCon CNP
Long-acting CNP prodrug
Data not indexed yet
0 studies
Open record →Published evidence
Studies
No dead ends
Continue Exploring
BI
Growth Plate
biological process
Chondrocyte proliferation, hypertrophy, differentiation and endochondral ossification.
15 pathway5 target12 compound7 study→
CEChondrocytes
cell type
Primary cell type responsible for cartilage matrix formation and growth-plate activity.
10 pathway3 target4 compound1 study→
COCNP
compound
C-type natriuretic peptide
12 pathway4 target9 compound1 study→
COVosoritide
compound
CNP analogue
12 pathway4 target8 compound1 study→
CONavepegritide / TransCon CNP
compound
Long-acting CNP prodrug
12 pathway4 target8 compound1 study→