IGF-1
Insulin-like growth factor 1
Data not indexed yet
0 studies
Open record →Tissue
Cartilage
Avascular connective tissue whose specialized cells maintain a proteoglycan-rich matrix.
At a glance
Research Summary
- What is it?
- Avascular connective tissue whose specialized cells maintain a proteoglycan-rich matrix.
- Why does it matter?
- This tissue provides anatomical context for 1 cell types and 6 connected pathways.
- Key mechanisms
- GH / IGF-1 Axis · IGF1R → PI3K → AKT · CNP / NPR-B Signaling · MAPK · FGFR3 / MAPK Signaling · cGMP Signaling
- Key targets
- NPR2 / NPR-B · FGFR3 · IGF1R
- Related compounds
- IGF-1 · CNP · Vosoritide · Navepegritide / TransCon CNP
- Human evidence
- No human studies indexed for this node.
- Main uncertainties
- The current index is curated but not exhaustive.
Cell types
Relevant pathways
PA
GH / IGF-1 Axis
pathway
Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
14 pathway6 target27 compound7 study→
PAIGF1R → PI3K → AKT
pathway
Cascata de receptor tirosina-quinase associada a crescimento, sobrevivência e metabolismo celular.
5 pathway2 target19 compound6 study→
PACNP / NPR-B Signaling
pathway
Sinalização do receptor guanilato ciclase NPR-B por CNP, relevante à biologia da cartilagem de crescimento.
9 pathway4 target10 compound1 study→
PAMAPK
pathway
Família de cascatas quinase que transmite sinais de superfície ao programa celular.
8 pathway3 target9 compound1 study→
PAFGFR3 / MAPK Signaling
pathway
Sinalização de FGFR3 através de cascatas RAS/RAF/MEK/ERK, com efeitos dependentes do contexto na placa de crescimento.
8 pathway3 target9 compound→
PAcGMP Signaling
pathway
Rede de segundo mensageiro gerada por guanilato ciclases e interpretada por proteínas quinase dependentes de cGMP.
8 pathway1 target4 compound1 study→
Related Compounds
CNP
C-type natriuretic peptide
Data not indexed yet
0 studies
Open record →Vosoritide
CNP analogue
Human RCT
1 study
Open record →Navepegritide / TransCon CNP
Long-acting CNP prodrug
Data not indexed yet
0 studies
Open record →Published evidence
Studies
No dead ends
Continue Exploring
CE
Chondrocytes
cell type
Primary cell type responsible for cartilage matrix formation and growth-plate activity.
10 pathway3 target4 compound1 study→
COIGF-1
compound
Insulin-like growth factor 1
18 pathway6 target18 compound7 study→
COCNP
compound
C-type natriuretic peptide
12 pathway4 target9 compound1 study→
COVosoritide
compound
CNP analogue
12 pathway4 target8 compound1 study→
CONavepegritide / TransCon CNP
compound
Long-acting CNP prodrug
12 pathway4 target8 compound1 study→