IGF-1
Insulin-like growth factor 1
Data not indexed yet
0 studies
Open record →Tissue
Bone
Mineralized connective tissue maintained by coordinated formation and resorption.
At a glance
Research Summary
- What is it?
- Mineralized connective tissue maintained by coordinated formation and resorption.
- Why does it matter?
- This tissue provides anatomical context for 3 cell types and 7 connected pathways.
- Key mechanisms
- GH / IGF-1 Axis · IGF1R → PI3K → AKT · CNP / NPR-B Signaling · PTH / PTH1R Signaling · IHH / PTHrP Feedback · cGMP Signaling · MAPK
- Key targets
- IGF1R · NPR2 / NPR-B · PTH1R
- Related compounds
- IGF-1 · CNP · Vosoritide · Teriparatide · Abaloparatide
- Human evidence
- No human studies indexed for this node.
- Main uncertainties
- The current index is curated but not exhaustive.
Cell types
CE
Osteoblasts
cell type
Bone-forming cells that synthesize osteoid and participate in mineralization.
5 pathway3 target6 compound1 study→
CEOsteoclasts
cell type
Multinucleated cells specialized for resorption of mineralized bone.
5 pathway3 target6 compound1 study→
CEOsteocytes
cell type
Mature bone cells embedded in matrix that participate in mechanosensing and remodeling signals.
5 pathway3 target5 compound1 study→
Biological processes
Relevant pathways
PA
GH / IGF-1 Axis
pathway
Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
14 pathway6 target27 compound7 study→
PAIGF1R → PI3K → AKT
pathway
Cascata de receptor tirosina-quinase associada a crescimento, sobrevivência e metabolismo celular.
5 pathway2 target19 compound6 study→
PACNP / NPR-B Signaling
pathway
Sinalização do receptor guanilato ciclase NPR-B por CNP, relevante à biologia da cartilagem de crescimento.
9 pathway4 target10 compound1 study→
PAPTH / PTH1R Signaling
pathway
Sinalização de PTH1R por PTH e PTHrP através de múltiplos efetores, incluindo cAMP/PKA.
2 pathway1 target14 compound→
PAIHH / PTHrP Feedback
pathway
Circuito regulatório entre Indian hedgehog e PTHrP associado à progressão de estados de diferenciação dos condrócitos.
9 pathway3 target14 compound→
PAcGMP Signaling
pathway
Rede de segundo mensageiro gerada por guanilato ciclases e interpretada por proteínas quinase dependentes de cGMP.
8 pathway1 target4 compound1 study→
PAMAPK
pathway
Família de cascatas quinase que transmite sinais de superfície ao programa celular.
8 pathway3 target9 compound1 study→
Related Compounds
CNP
C-type natriuretic peptide
Data not indexed yet
0 studies
Open record →Vosoritide
CNP analogue
Human RCT
1 study
Open record →Teriparatide
PTH(1–34) analogue
Data not indexed yet
0 studies
Open record →Abaloparatide
PTHrP analogue
Data not indexed yet
0 studies
Open record →Published evidence
Studies
No dead ends
Continue Exploring
CE
Osteoblasts
cell type
Bone-forming cells that synthesize osteoid and participate in mineralization.
5 pathway3 target6 compound1 study→
CEOsteoclasts
cell type
Multinucleated cells specialized for resorption of mineralized bone.
5 pathway3 target6 compound1 study→
CEOsteocytes
cell type
Mature bone cells embedded in matrix that participate in mechanosensing and remodeling signals.
5 pathway3 target5 compound1 study→
COIGF-1
compound
Insulin-like growth factor 1
18 pathway6 target18 compound7 study→
COCNP
compound
C-type natriuretic peptide
12 pathway4 target9 compound1 study→
COVosoritide
compound
CNP analogue
12 pathway4 target8 compound1 study→
COTeriparatide
compound
PTH(1–34) analogue
15 pathway5 target13 compound7 study→
COAbaloparatide
compound
PTHrP analogue
15 pathway5 target13 compound7 study→