Tesamorelin
Stabilized GHRH analogue
Human RCT
1 study
Open record →Tissue
Adipose Tissue
Energy-storing and endocrine tissue composed of adipocytes and stromal cells.
At a glance
Research Summary
- What is it?
- Energy-storing and endocrine tissue composed of adipocytes and stromal cells.
- Why does it matter?
- This tissue provides anatomical context for 0 cell types and 7 connected pathways.
- Key mechanisms
- GHRH Signaling · GH / IGF-1 Axis · GLP-1 Signaling · IGF1R → PI3K → AKT · AMPK · cAMP Signaling · Glucagon Signaling
- Key targets
- GHRHR · GIPR · GLP1R · GCGR
- Related compounds
- Tesamorelin · Retatrutide · Tirzepatide · Semaglutide · AOD-9604
- Human evidence
- No human studies indexed for this node.
- Main uncertainties
- The current index is curated but not exhaustive.
Relevant pathways
PA
GHRH Signaling
pathway
Ativação de GHRHR em somatotrofos com sinalização Gs, adenilil ciclase, cAMP e PKA.
6 pathway3 target21 compound6 study→
PAGH / IGF-1 Axis
pathway
Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
14 pathway6 target27 compound7 study→
PAGLP-1 Signaling
pathway
Sinalização de GLP-1R relacionada a secreção de insulina, esvaziamento gástrico e circuitos de saciedade.
6 pathway4 target19 compound7 study→
PAIGF1R → PI3K → AKT
pathway
Cascata de receptor tirosina-quinase associada a crescimento, sobrevivência e metabolismo celular.
5 pathway2 target19 compound6 study→
PAAMPK
pathway
Sensor celular de energia que coordena respostas ao estado energético.
5 pathway4 target11 compound2 study→
PAcAMP Signaling
pathway
Rede de segundo mensageiro gerada por adenilil ciclase e interpretada por efetores como PKA e EPAC.
6 pathway5 target20 compound7 study→
PAGlucagon Signaling
pathway
Sinalização de GCGR com efeitos metabólicos predominantes no fígado e dependentes do estado nutricional.
2 pathway3 target8 compound→
Related Compounds
Retatrutide
GIPR / GLP-1R / GCGR agonist
Data not indexed yet
0 studies
Open record →Tirzepatide
GIPR / GLP-1R agonist
Data not indexed yet
0 studies
Open record →Semaglutide
GLP-1 receptor agonist
Human RCT
1 study
Open record →AOD-9604
Modified hGH fragment
Mecanismo estruturado ainda não indexado.
Data not indexed yet
0 studies
Open record →Published evidence
Studies
No dead ends
Continue Exploring
CO
Tesamorelin
compound
Stabilized GHRH analogue
18 pathway8 target26 compound7 study→
CORetatrutide
compound
GIPR / GLP-1R / GCGR agonist
7 pathway5 target16 compound2 study→
COTirzepatide
compound
GIPR / GLP-1R agonist
7 pathway5 target16 compound2 study→
COSemaglutide
compound
GLP-1 receptor agonist
7 pathway5 target16 compound2 study→
COAOD-9604
compound
Modified hGH fragment
5 pathway4 target4 compound2 study→