CNP
C-type natriuretic peptide
Data not indexed yet
0 studies
Open record →Biological Target
NPR2 / NPR-B
NPR-B · Natriuretic peptide receptor B · Guanylyl cyclase B
NPR2 / NPR-B is a membrane guanylyl cyclase receptor connected to cGMP, PKG, RAF / MEK / ERK modulation.
At a glance
Research Summary
- What is it?
- Receptor: Membrane guanylyl cyclase receptor
- Why does it matter?
- This target connects ligands and 3 indexed compounds to downstream signaling.
- Key mechanisms
- CNP / NPR-B Signaling · MAPK
- Key targets
- NPR2 / NPR-B
- Related compounds
- CNP · Vosoritide · Navepegritide / TransCon CNP
- Human evidence
- 1 related study records are currently indexed.
- Main uncertainties
- Tissue expression and downstream effects vary by cell state, dose and experimental context.
Target profile
Canonical details
- Canonical name
- NPR2 / NPR-B
- Aliases
- NPR-B, Natriuretic peptide receptor B, Guanylyl cyclase B
- Target type
- Receptor
- Receptor class
- Membrane guanylyl cyclase receptor
- Endogenous ligands
- CNP
- Downstream signaling
- cGMP → PKG → RAF / MEK / ERK modulation
Curated relationships
direct
CNP and CNP analogues activate the membrane guanylyl cyclase NPR2/NPR-B.
mixedindirect
CNP/NPR2/cGMP signaling can oppose FGFR3-linked RAF/MEK/ERK signaling in growth-plate models.
mechanisticdirect
NPR2 / NPR-B expressed in Chondrocytes.
mixeddirect
CNP acts on NPR2 / NPR-B.
scope not indexeddirect
Vosoritide acts on NPR2 / NPR-B.
scope not indexeddirect
Navepegritide / TransCon CNP acts on NPR2 / NPR-B.
scope not indexedPathways, tissues and cells
PA
CNP / NPR-B Signaling
pathway
Sinalização do receptor guanilato ciclase NPR-B por CNP, relevante à biologia da cartilagem de crescimento.
9 pathway4 target10 compound1 study→
PAMAPK
pathway
Família de cascatas quinase que transmite sinais de superfície ao programa celular.
8 pathway3 target9 compound1 study→
TIGrowth Plate
tissue
Organized cartilage zones that support longitudinal bone growth before epiphyseal closure.
9 pathway3 target10 compound1 study→
TICartilage
tissue
Avascular connective tissue whose specialized cells maintain a proteoglycan-rich matrix.
6 pathway3 target20 compound1 study→
TIBone
tissue
Mineralized connective tissue maintained by coordinated formation and resorption.
7 pathway3 target24 compound1 study→
CEChondrocytes
cell type
Primary cell type responsible for cartilage matrix formation and growth-plate activity.
10 pathway3 target4 compound1 study→
Related Compounds
Vosoritide
CNP analogue
Human RCT
1 study
Open record →Navepegritide / TransCon CNP
Long-acting CNP prodrug
Data not indexed yet
0 studies
Open record →Published evidence
Studies
No dead ends
Continue Exploring
PA
CNP / NPR-B Signaling
pathway
Sinalização do receptor guanilato ciclase NPR-B por CNP, relevante à biologia da cartilagem de crescimento.
9 pathway4 target10 compound1 study→
PAMAPK
pathway
Família de cascatas quinase que transmite sinais de superfície ao programa celular.
8 pathway3 target9 compound1 study→
CEChondrocytes
cell type
Primary cell type responsible for cartilage matrix formation and growth-plate activity.
10 pathway3 target4 compound1 study→
COCNP
compound
C-type natriuretic peptide
12 pathway4 target9 compound1 study→
COVosoritide
compound
CNP analogue
12 pathway4 target8 compound1 study→
CONavepegritide / TransCon CNP
compound
Long-acting CNP prodrug
12 pathway4 target8 compound1 study→