Retatrutide
GIPR / GLP-1R / GCGR agonist
Data not indexed yet
0 studies
Open record →Biological Target
GLP1R
GLP-1R · Glucagon-like peptide 1 receptor
GLP1R is a class b g protein-coupled receptor connected to Gs, Adenylyl cyclase, cAMP, PKA / EPAC.
At a glance
Research Summary
- What is it?
- Receptor: Class B G protein-coupled receptor
- Why does it matter?
- This target connects ligands and 3 indexed compounds to downstream signaling.
- Key mechanisms
- GLP-1 Signaling
- Key targets
- GLP1R
- Related compounds
- Retatrutide · Tirzepatide · Semaglutide
- Human evidence
- 1 related study records are currently indexed.
- Main uncertainties
- Tissue expression and downstream effects vary by cell state, dose and experimental context.
Target profile
Canonical details
- Canonical name
- GLP1R
- Aliases
- GLP-1R, Glucagon-like peptide 1 receptor
- Target type
- Receptor
- Receptor class
- Class B G protein-coupled receptor
- Endogenous ligands
- GLP-1
- Downstream signaling
- Gs → Adenylyl cyclase → cAMP → PKA / EPAC
Curated relationships
direct
GLP-1 Signaling acts on GLP1R.
mixeddirect
GLP1R expressed in Pancreatic Beta Cells.
mixeddirect
GLP1R expressed in Brain.
mixeddirect
Retatrutide acts on GLP1R.
scope not indexeddirect
Tirzepatide acts on GLP1R.
scope not indexeddirect
Semaglutide acts on GLP1R.
scope not indexedPathways, tissues and cells
PA
GLP-1 Signaling
pathway
Sinalização de GLP-1R relacionada a secreção de insulina, esvaziamento gástrico e circuitos de saciedade.
6 pathway4 target19 compound7 study→
TIBrain
tissue
Central nervous system tissue integrating neural, endocrine and metabolic signals.
5 pathway5 target24 compound1 study→
TIGI Tract
tissue
Digestive tissues that also produce and respond to peptide signals.
4 pathway3 target13 compound1 study→
TIAdipose Tissue
tissue
Energy-storing and endocrine tissue composed of adipocytes and stromal cells.
7 pathway5 target25 compound2 study→
CEPancreatic Beta Cells
cell type
Endocrine pancreatic cells responsible for insulin secretion.
2 pathway3 target9 compound1 study→
Related Compounds
Tirzepatide
GIPR / GLP-1R agonist
Data not indexed yet
0 studies
Open record →Semaglutide
GLP-1 receptor agonist
Human RCT
1 study
Open record →Published evidence
Studies
No dead ends
Continue Exploring
PA
GLP-1 Signaling
pathway
Sinalização de GLP-1R relacionada a secreção de insulina, esvaziamento gástrico e circuitos de saciedade.
6 pathway4 target19 compound7 study→
CEPancreatic Beta Cells
cell type
Endocrine pancreatic cells responsible for insulin secretion.
2 pathway3 target9 compound1 study→
TIBrain
tissue
Central nervous system tissue integrating neural, endocrine and metabolic signals.
5 pathway5 target24 compound1 study→
CORetatrutide
compound
GIPR / GLP-1R / GCGR agonist
7 pathway5 target16 compound2 study→
COTirzepatide
compound
GIPR / GLP-1R agonist
7 pathway5 target16 compound2 study→
COSemaglutide
compound
GLP-1 receptor agonist
7 pathway5 target16 compound2 study→