Retatrutide
GIPR / GLP-1R / GCGR agonist
Data not indexed yet
0 studies
Open record →Biological Target
GCGR
Glucagon receptor
GCGR is a class b g protein-coupled receptor connected to Gs, cAMP, PKA.
At a glance
Research Summary
- What is it?
- Receptor: Class B G protein-coupled receptor
- Why does it matter?
- This target connects ligands and 1 indexed compounds to downstream signaling.
- Key mechanisms
- Glucagon Signaling
- Key targets
- GCGR
- Related compounds
- Retatrutide
- Human evidence
- 0 related study records are currently indexed.
- Main uncertainties
- Tissue expression and downstream effects vary by cell state, dose and experimental context.
Target profile
Canonical details
- Canonical name
- GCGR
- Aliases
- Glucagon receptor
- Target type
- Receptor
- Receptor class
- Class B G protein-coupled receptor
- Endogenous ligands
- Glucagon
- Downstream signaling
- Gs → cAMP → PKA
Curated relationships
direct
Glucagon Signaling acts on GCGR.
mechanisticdirect
Retatrutide acts on GCGR.
scope not indexedPathways, tissues and cells
PA
Glucagon Signaling
pathway
Sinalização de GCGR com efeitos metabólicos predominantes no fígado e dependentes do estado nutricional.
2 pathway3 target8 compound→
TIBrain
tissue
Central nervous system tissue integrating neural, endocrine and metabolic signals.
5 pathway5 target24 compound1 study→
TIGI Tract
tissue
Digestive tissues that also produce and respond to peptide signals.
4 pathway3 target13 compound1 study→
TIAdipose Tissue
tissue
Energy-storing and endocrine tissue composed of adipocytes and stromal cells.
7 pathway5 target25 compound2 study→
Related Compounds
Published evidence
Studies
No studies in this evidence category are indexed for this node.
No dead ends