In VitroCell culture
The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures
A. Siméon, H. Emonard, W. Hornebeck, F. X. Maquart
Study design
Methods snapshot
- Population
- Fibroblast cultures
- Sample size
- Not indexed
- Intervention
- GHK-Cu
- Route
- Not indexed
- Dose reported
- Not indexed
- Frequency
- Not indexed
- Duration
- Not indexed
- Control / placebo
- Not indexed
Outcomes
Primary
- MMP-2 expression
Results
GHK-Cu exposure was associated with increased MMP-2 expression in fibroblast culture.
Interpretation
Mechanistic evidence for matrix proteolysis regulation, not proof of net clinical remodeling benefit.
Adverse events
Not indexed in the current record.
Limitations
- In vitro expression outcome
- Matrix-remodeling effects are context dependent
Connected records
Original source
Sempre consulte o artigo original para métodos completos, análises e contexto editorial.
Open PubMed record ↗