AnimalMouse
Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse
M. Alba, D. Fintini, A. Sagazio, B. Lawrence, J. P. Castaigne, L. A. Frohman, R. Salvatori
American Journal of Physiology-Endocrinology and Metabolism•2006DOI 10.1152/ajpendo.00201.2006PubMed 16822960
Study design
Methods snapshot
- Population
- GHRH-knockout mice
- Sample size
- Not indexed
- Intervention
- CJC-1295
- Route
- Not indexed
- Dose reported
- Not indexed
- Frequency
- Once daily
- Duration
- Not indexed
- Control / placebo
- Not indexed
Outcomes
Primary
- Body growth
- GH/IGF-axis markers
Results
Daily CJC-1295 administration increased growth in the GHRH-knockout mouse model.
Interpretation
Preclinical evidence of GHRHR-mediated biological activity.
Adverse events
Not indexed in the current record.
Limitations
- Genetically altered animal model
- Cannot establish a human growth indication
Connected records
Original source
Sempre consulte o artigo original para métodos completos, análises e contexto editorial.
Open PubMed record ↗