IGF-1
Insulin-like growth factor 1
Data not indexed yet
0 studies
Open record →Research Area
Bone & Skeletal Research
Placa de crescimento, cartilagem, osteoblastos, osteoclastos e remodelação óssea.
At a glance
Research Summary
- What is it?
- Placa de crescimento, cartilagem, osteoblastos, osteoclastos e remodelação óssea.
- Why does it matter?
- `This hub organizes ${processes.length} biological processes without treating a research category as a causal mechanism.`
- Key mechanisms
- CNP / NPR-B Signaling · GH / IGF-1 Axis · MAPK · FGFR3 / MAPK Signaling · IHH / PTHrP Feedback
- Key targets
- Not indexed yet
- Related compounds
- IGF-1 · CNP · Vosoritide · Navepegritide / TransCon CNP · Teriparatide
- Human evidence
- 1 directly or transitively connected human/curated study records are currently indexed.
- Main uncertainties
- Coverage is selective. A missing connection means it has not been curated here, not that no relationship exists.
Choose a level
What do you want to explore?
01
Longitudinal Growth
biological process
Increase in long-bone length through coordinated growth-plate activity and endochondral ossification.
11 pathway3 target6 compound1 study→
02Growth Plate
biological process
Chondrocyte proliferation, hypertrophy, differentiation and endochondral ossification.
15 pathway5 target12 compound7 study→
03Cartilage Biology
biological process
Cellular and extracellular-matrix biology of articular and growth-plate cartilage.
11 pathway3 target6 compound1 study→
04Bone Remodeling
biological process
Coupled resorption and formation that renews mineralized bone.
11 pathway3 target6 compound1 study→
05Bone Density
biological process
Determinants of bone mass, mineral content and structural integrity.
11 pathway3 target6 compound1 study→
06Osteoblast Activity
biological process
Matrix synthesis and mineralization by bone-forming cells.
11 pathway3 target6 compound1 study→
07Osteoclast Activity
biological process
Resorption of mineralized bone by multinucleated osteoclasts.
11 pathway3 target6 compound1 study→
08Fracture Repair
biological process
Inflammation, callus formation, angiogenesis and remodeling after bone injury.
11 pathway3 target6 compound1 study→
09Mineralization
biological process
Deposition and organization of mineral within extracellular matrix.
11 pathway3 target6 compound1 study→
10Endochondral Ossification
biological process
Replacement of a cartilage template by bone during development and repair.
12 pathway3 target6 compound1 study→
Key pathways
PA
CNP / NPR-B Signaling
pathway
Sinalização do receptor guanilato ciclase NPR-B por CNP, relevante à biologia da cartilagem de crescimento.
9 pathway4 target10 compound1 study→
PAGH / IGF-1 Axis
pathway
Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
14 pathway6 target27 compound7 study→
PAMAPK
pathway
Família de cascatas quinase que transmite sinais de superfície ao programa celular.
8 pathway3 target9 compound1 study→
PAFGFR3 / MAPK Signaling
pathway
Sinalização de FGFR3 através de cascatas RAS/RAF/MEK/ERK, com efeitos dependentes do contexto na placa de crescimento.
8 pathway3 target9 compound→
PAIHH / PTHrP Feedback
pathway
Circuito regulatório entre Indian hedgehog e PTHrP associado à progressão de estados de diferenciação dos condrócitos.
9 pathway3 target14 compound→
PABMP Signaling
pathway
Sinalização de bone morphogenetic proteins por receptores serina/treonina-quinase e SMADs.
8 pathway3 target9 compound→
Key cell types
CE
Osteoblasts
cell type
Bone-forming cells that synthesize osteoid and participate in mineralization.
5 pathway3 target6 compound1 study→
CEOsteoclasts
cell type
Multinucleated cells specialized for resorption of mineralized bone.
5 pathway3 target6 compound1 study→
CEChondrocytes
cell type
Primary cell type responsible for cartilage matrix formation and growth-plate activity.
10 pathway3 target4 compound1 study→
CEOsteocytes
cell type
Mature bone cells embedded in matrix that participate in mechanosensing and remodeling signals.
5 pathway3 target5 compound1 study→
CEMyocytes
cell type
Differentiated contractile muscle cells.
3 pathway1 target6 compound→
CESatellite Cells
cell type
Resident skeletal-muscle progenitor cells involved in repair and adaptation.
3 pathway1 target6 compound→
Connected records
Related Compounds
CNP
C-type natriuretic peptide
Data not indexed yet
0 studies
Open record →Vosoritide
CNP analogue
Human RCT
1 study
Open record →Navepegritide / TransCon CNP
Long-acting CNP prodrug
Data not indexed yet
0 studies
Open record →Teriparatide
PTH(1–34) analogue
Data not indexed yet
0 studies
Open record →Abaloparatide
PTHrP analogue
Data not indexed yet
0 studies
Open record →Published evidence