CJC-1295
Long-acting GHRH analogue with Drug Affinity Complex
Human RCTHuman ClinicalAnimal
5 studies
Open record →Biological Pathway / GHRHR
GHRH Signaling
Ativação de GHRHR em somatotrofos com sinalização Gs, adenilil ciclase, cAMP e PKA.
At a glance
Research Summary
- What is it?
- Ativação de GHRHR em somatotrofos com sinalização Gs, adenilil ciclase, cAMP e PKA.
- Why does it matter?
- GHRH Signaling connects 1 targets to 1 curated biological processes.
- Key mechanisms
- GHRHR · Gs · Adenylyl cyclase · cAMP · PKA · GH release
- Key targets
- GHRHR
- Related compounds
- CJC-1295 · CJC-1295 without DAC · Sermorelin · Tesamorelin
- Human evidence
- 6 related published study records are indexed.
- Main uncertainties
- Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.
Pathway profile
Canonical details
- Primary ligand
- Context dependent
- Target / receptor
- GHRHR
- Second messenger
- cAMP
- Downstream pathway
- cAMP → PKA → GH release
- Cell types
- Pituitary Somatotrophs
- Tissues
- Pituitary, Liver, Adipose Tissue
- Physiological processes
- Pituitary GH Release
- Known uncertainties
- Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.
Complementary visualization
Mechanism
GHRHR
↓
Gs
↓
Adenylyl cyclase
↓
cAMP
↓
PKA
↓
GH release
Arrows show a curated signaling sequence. They do not imply that every transition is a direct physical interaction.
Relationship evidence
directscope not indexed
Pituitary GH Release associated with GHRH Signaling.
directmechanistic
GHRH Signaling part of cAMP Signaling.
directhuman
GHRHR signaling stimulates pituitary GH release while secretion remained pulsatile in the indexed CJC-1295 analysis.
associatedscope not indexed
GHRH Signaling associated with CJC-1295.
associatedscope not indexed
GHRH Signaling associated with CJC-1295 without DAC.
associatedscope not indexed
GHRH Signaling associated with Sermorelin.
associatedscope not indexed
GHRH Signaling associated with Tesamorelin.
associatedscope not indexed
Growth Hormone associated with GHRH Signaling.
Related Compounds
CJC-1295 without DAC
Catalogue term often associated with Modified GRF (1–29)
Data not indexed yet
0 studies
Open record →Sermorelin
GHRH(1–29) analogue
Data not indexed yet
0 studies
Open record →Tesamorelin
Stabilized GHRH analogue
Human RCT
1 study
Open record →Related topics
Published evidence
Studies
human-rctProlonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalPulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analogJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalActivation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjectsGrowth Hormone & IGF Research · 2009animalOnce-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouseAmerican Journal of Physiology-Endocrinology and Metabolism · 2006animalHuman growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analogEndocrinology · 2005human-rctEffect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trialJAMA · 2014
No dead ends
Continue Exploring
BI
Pituitary GH Release
biological process
Synthesis and pulsatile release of growth hormone by pituitary somatotrophs.
8 pathway3 target10 compound6 study→
TAGHRHR
target
GHRHR is a class b g protein-coupled receptor connected to Gs, Adenylyl cyclase, cAMP, PKA, GH release.
7 pathway1 target21 compound6 study→
PAcAMP Signaling
pathway
Rede de segundo mensageiro gerada por adenilil ciclase e interpretada por efetores como PKA e EPAC.
6 pathway5 target20 compound7 study→
COCJC-1295
compound
Long-acting GHRH analogue with Drug Affinity Complex
16 pathway6 target22 compound6 study→
COCJC-1295 without DAC
compound
Catalogue term often associated with Modified GRF (1–29)
10 pathway5 target16 compound6 study→
COSermorelin
compound
GHRH(1–29) analogue
16 pathway5 target19 compound6 study→
COTesamorelin
compound
Stabilized GHRH analogue
18 pathway8 target26 compound7 study→
TOGrowth Hormone
topic
Hormônio peptídico pituitário integrado ao eixo somatotrófico.
13 pathway3 target20 compound6 study→