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Biological Pathway

GH / IGF-1 Axis

Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.

At a glance

Research Summary

What is it?
Eixo endócrino que conecta sinalização hipotalâmica e pituitária à produção e ação de IGF-1.
Why does it matter?
GH / IGF-1 Axis connects 0 targets to 1 curated biological processes.
Key mechanisms
Hypothalamic signals · Pituitary somatotroph · Growth hormone · Hepatic and local IGF-1 · IGF1R signaling
Key targets
Not indexed yet
Related compounds
CJC-1295 · Sermorelin · Tesamorelin · IGF-1
Human evidence
6 related published study records are indexed.
Main uncertainties
Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.

Pathway profile

Canonical details

Primary ligand
IGF-1
Target / receptor
Not indexed yet
Second messenger
Not indexed
Downstream pathway
Growth hormone → Hepatic and local IGF-1 → IGF1R signaling
Cell types
Not indexed yet
Tissues
Growth Plate, Pituitary, Liver, Adipose Tissue, Bone, Cartilage, Skeletal Muscle
Physiological processes
Growth Plate
Known uncertainties
Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.

Complementary visualization

Mechanism

Hypothalamic signals
↓
Pituitary somatotroph
↓
Growth hormone
↓
Hepatic and local IGF-1
↓
IGF1R signaling

Arrows show a curated signaling sequence. They do not imply that every transition is a direct physical interaction.

Relationship evidence

associated

Growth Plate associated with GH / IGF-1 Axis.

scope not indexed
associated

GH / IGF-1 Axis associated with CJC-1295.

scope not indexed
associated

GH / IGF-1 Axis associated with Sermorelin.

scope not indexed
associated

GH / IGF-1 Axis associated with Tesamorelin.

scope not indexed
associated

GH / IGF-1 Axis associated with IGF-1.

scope not indexed
associated

Growth Plate associated with GH / IGF-1 Axis.

scope not indexed
associated

Growth Hormone associated with GH / IGF-1 Axis.

scope not indexed
associated

IGF-1 associated with GH / IGF-1 Axis.

scope not indexed

Related Compounds

Related topics

TO

Growth Plate

topic

Cartilagem organizada responsável pelo crescimento longitudinal ósseo durante o desenvolvimento.

13 pathway3 target20 compound7 study→
TO

Growth Hormone

topic

Hormônio peptídico pituitário integrado ao eixo somatotrófico.

13 pathway3 target20 compound6 study→
TO

IGF-1

topic

Fator de crescimento que atua por IGF1R e participa de múltiplos processos de crescimento e metabolismo.

14 pathway3 target27 compound6 study→

Published evidence

Studies

human-rctProlonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalPulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analogJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalActivation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjectsGrowth Hormone & IGF Research · 2009animalOnce-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouseAmerican Journal of Physiology-Endocrinology and Metabolism · 2006animalHuman growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analogEndocrinology · 2005human-rctEffect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trialJAMA · 2014

No dead ends

Continue Exploring

BI

Growth Plate

biological process

Chondrocyte proliferation, hypertrophy, differentiation and endochondral ossification.

15 pathway5 target12 compound7 study→
CO

CJC-1295

compound

Long-acting GHRH analogue with Drug Affinity Complex

16 pathway6 target22 compound6 study→
CO

Sermorelin

compound

GHRH(1–29) analogue

16 pathway5 target19 compound6 study→
CO

Tesamorelin

compound

Stabilized GHRH analogue

18 pathway8 target26 compound7 study→
CO

IGF-1

compound

Insulin-like growth factor 1

18 pathway6 target18 compound7 study→
TO

Growth Plate

topic

Cartilagem organizada responsável pelo crescimento longitudinal ósseo durante o desenvolvimento.

13 pathway3 target20 compound7 study→
TO

Growth Hormone

topic

Hormônio peptídico pituitário integrado ao eixo somatotrófico.

13 pathway3 target20 compound6 study→
TO

IGF-1

topic

Fator de crescimento que atua por IGF1R e participa de múltiplos processos de crescimento e metabolismo.

14 pathway3 target27 compound6 study→