CNP
C-type natriuretic peptide
Data not indexed yet
0 studies
Open record →Biological Pathway / NPR-B
CNP / NPR-B Signaling
Sinalização do receptor guanilato ciclase NPR-B por CNP, relevante à biologia da cartilagem de crescimento.
At a glance
Research Summary
- What is it?
- Sinalização do receptor guanilato ciclase NPR-B por CNP, relevante à biologia da cartilagem de crescimento.
- Why does it matter?
- CNP / NPR-B Signaling connects 1 targets to 2 curated biological processes.
- Key mechanisms
- CNP or analogue · NPR-B · Guanylyl cyclase · cGMP · PKG · RAF / MEK / ERK modulation · Chondrocyte biology · Endochondral ossification
- Key targets
- NPR2 / NPR-B
- Related compounds
- CNP · Vosoritide · Navepegritide / TransCon CNP
- Human evidence
- 1 related published study records are indexed.
- Main uncertainties
- Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.
Pathway profile
Canonical details
- Primary ligand
- CNP
- Target / receptor
- NPR2 / NPR-B
- Second messenger
- cGMP
- Downstream pathway
- RAF / MEK / ERK modulation → Chondrocyte biology → Endochondral ossification
- Cell types
- Chondrocytes
- Tissues
- Growth Plate, Bone, Cartilage, Skeletal Muscle, Liver
- Physiological processes
- Growth Plate, Endochondral Ossification
- Known uncertainties
- Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.
Complementary visualization
Mechanism
CNP or analogue
↓
NPR-B ↓
Guanylyl cyclase
↓
cGMP
↓
PKG
↓
RAF / MEK / ERK modulation
↓
Chondrocyte biology
↓
Endochondral ossificationArrows show a curated signaling sequence. They do not imply that every transition is a direct physical interaction.
Relationship evidence
directscope not indexed
CNP / NPR-B Signaling part of cGMP Signaling.
associatedscope not indexed
CNP / NPR-B Signaling associated with CNP.
associatedscope not indexed
CNP / NPR-B Signaling associated with Vosoritide.
associatedscope not indexed
CNP / NPR-B Signaling associated with Navepegritide / TransCon CNP.
associatedscope not indexed
Growth Plate associated with CNP / NPR-B Signaling.
associatedscope not indexed
Chondrocytes associated with CNP / NPR-B Signaling.
Related Compounds
Vosoritide
CNP analogue
Human RCT
1 study
Open record →Navepegritide / TransCon CNP
Long-acting CNP prodrug
Data not indexed yet
0 studies
Open record →Related topics
Published evidence
Studies
No dead ends
Continue Exploring
BI
Growth Plate
biological process
Chondrocyte proliferation, hypertrophy, differentiation and endochondral ossification.
15 pathway5 target12 compound7 study→
BIEndochondral Ossification
biological process
Replacement of a cartilage template by bone during development and repair.
12 pathway3 target6 compound1 study→
TANPR2 / NPR-B
target
NPR2 / NPR-B is a membrane guanylyl cyclase receptor connected to cGMP, PKG, RAF / MEK / ERK modulation.
9 pathway1 target7 compound1 study→
PAcGMP Signaling
pathway
Rede de segundo mensageiro gerada por guanilato ciclases e interpretada por proteínas quinase dependentes de cGMP.
8 pathway1 target4 compound1 study→
COCNP
compound
C-type natriuretic peptide
12 pathway4 target9 compound1 study→
COVosoritide
compound
CNP analogue
12 pathway4 target8 compound1 study→
CONavepegritide / TransCon CNP
compound
Long-acting CNP prodrug
12 pathway4 target8 compound1 study→
TOGrowth Plate
topic
Cartilagem organizada responsável pelo crescimento longitudinal ósseo durante o desenvolvimento.
13 pathway3 target20 compound7 study→