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Biological Pathway

cAMP Signaling

Rede de segundo mensageiro gerada por adenilil ciclase e interpretada por efetores como PKA e EPAC.

At a glance

Research Summary

What is it?: Rede de segundo mensageiro gerada por adenilil ciclase e interpretada por efetores como PKA e EPAC.
Why does it matter?: cAMP Signaling connects 0 targets to 0 curated biological processes.
Key mechanisms: Gs-coupled receptor · Adenylyl cyclase · cAMP · PKA / EPAC · Context-dependent response
Key targets: Not indexed yet
Related compounds: CJC-1295
Human evidence: 5 related published study records are indexed.
Main uncertainties: Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.

Pathway profile

Canonical details

Primary ligand: Context dependent
Target / receptor: Not indexed yet
Second messenger: cAMP
Downstream pathway: cAMP → PKA / EPAC → Context-dependent response
Cell types: Not indexed yet
Tissues: Pituitary, Liver, Brain, GI Tract, Adipose Tissue
Physiological processes: Not indexed yet
Known uncertainties: Effects are tissue- and context-dependent; a pathway diagram is a curated model, not proof that every step is direct in every system.

Complementary visualization

Mechanism

Gs-coupled receptor

↓

Adenylyl cyclase

↓

cAMP

↓

PKA / EPAC

↓

Context-dependent response

Arrows show a curated signaling sequence. They do not imply that every transition is a direct physical interaction.

Relationship evidence

direct

GLP-1 Signaling part of cAMP Signaling.

mechanistic

direct

GHRH Signaling part of cAMP Signaling.

mechanistic

associated

cAMP Signaling associated with CJC-1295.

scope not indexed

Related Compounds

Long-acting GHRH analogue with Drug Affinity Complex

CJC-1295 with DAC → Albumin association → GHRHR → Gs → Adenylyl cyclase → cAMP → PKA → Pituitary somatotroph → Pulsatile GH secretion → Circulating IGF-1

gh igf axis endocrine hormonal

Human RCTHuman ClinicalAnimal

5 studies

Open record →

Published evidence

Studies

human-rctProlonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsJournal of Clinical Endocrinology & Metabolism · 2006 human-clinicalPulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analogJournal of Clinical Endocrinology & Metabolism · 2006 human-clinicalActivation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjectsGrowth Hormone & IGF Research · 2009 animalOnce-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouseAmerican Journal of Physiology-Endocrinology and Metabolism · 2006 animalHuman growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analogEndocrinology · 2005

No dead ends

Continue Exploring

GLP-1 Signaling

pathway

Sinalização de GLP-1R relacionada a secreção de insulina, esvaziamento gástrico e circuitos de saciedade.

6 pathway4 target19 compound7 study→

GHRH Signaling

pathway

Ativação de GHRHR em somatotrofos com sinalização Gs, adenilil ciclase, cAMP e PKA.

6 pathway3 target21 compound6 study→

CJC-1295

compound

Long-acting GHRH analogue with Drug Affinity Complex

16 pathway6 target22 compound6 study→