CJC-1295
Long-acting GHRH analogue with Drug Affinity Complex
Human RCTHuman ClinicalAnimal
5 studies
Open record →Cell Type
Pituitary Somatotrophs
Anterior-pituitary cells that synthesize and release growth hormone.
At a glance
Research Summary
- What is it?
- Anterior-pituitary cells that synthesize and release growth hormone.
- Why does it matter?
- This cell type is connected to 1 tissues and 0 biological processes in the current graph.
- Key mechanisms
- GHRH Signaling
- Key targets
- GHRHR · GHSR
- Related compounds
- CJC-1295 · CJC-1295 without DAC · Sermorelin · Tesamorelin · Ipamorelin · GHRP-2
- Human evidence
- No human studies indexed for this node.
- Main uncertainties
- The current index is curated but not exhaustive.
Tissues and processes
Pathways and targets
PA
GHRH Signaling
pathway
Ativação de GHRHR em somatotrofos com sinalização Gs, adenilil ciclase, cAMP e PKA.
6 pathway3 target21 compound6 study→
TAGHRHR
target
GHRHR is a class b g protein-coupled receptor connected to Gs, Adenylyl cyclase, cAMP, PKA, GH release.
7 pathway1 target21 compound6 study→
TAGHSR
target
GHSR is a class a g protein-coupled receptor connected to Gq/11, PLC, Intracellular calcium.
6 pathway2 target15 compound6 study→
Related Compounds
CJC-1295 without DAC
Catalogue term often associated with Modified GRF (1–29)
Data not indexed yet
0 studies
Open record →Sermorelin
GHRH(1–29) analogue
Data not indexed yet
0 studies
Open record →Tesamorelin
Stabilized GHRH analogue
Human RCT
1 study
Open record →Ipamorelin
Selective ghrelin receptor agonist
Data not indexed yet
0 studies
Open record →GHRP-2
Growth hormone secretagogue
Data not indexed yet
0 studies
Open record →GHRP-6
Growth hormone secretagogue
Data not indexed yet
0 studies
Open record →Hexarelin
Growth hormone secretagogue
Data not indexed yet
0 studies
Open record →Kisspeptin-10
Kisspeptin fragment
Mecanismo estruturado ainda não indexado.
Data not indexed yet
0 studies
Open record →Kisspeptin-54
Endogenous kisspeptin isoform
Mecanismo estruturado ainda não indexado.
Data not indexed yet
0 studies
Open record →Gonadorelin
Synthetic GnRH
Mecanismo estruturado ainda não indexado.
Data not indexed yet
0 studies
Open record →PT-141 / Bremelanotide
Melanocortin receptor agonist
Data not indexed yet
0 studies
Open record →Published evidence
Studies
human-rctProlonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalPulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analogJournal of Clinical Endocrinology & Metabolism · 2006human-clinicalActivation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjectsGrowth Hormone & IGF Research · 2009animalOnce-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouseAmerican Journal of Physiology-Endocrinology and Metabolism · 2006animalHuman growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analogEndocrinology · 2005human-rctEffect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trialJAMA · 2014
No dead ends